ID   MAST_VESOR              Reviewed;          14 AA.
AC   P17238;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Mastoparan;
DE   AltName: Full=Histamine-releasing peptide I;
DE            Short=HR-I;
OS   Vespa orientalis (Oriental hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=7447;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-14.
RC   TISSUE=Venom;
RA   Miroshnikov A.I., Snezhkova L.G., Nazimov I.V., Reshetova O.I.,
RA   Rozynov B.V., Gushchin I.S.;
RT   "Structure and properties of histamine releasing peptides from the venom of
RT   Vespa orientalis hornet.";
RL   Bioorg. Khim. 7:1467-1477(1981).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=2453223;
RA   Tuichibaev M.U., Akhmedova N.U., Kazakov I., Korneev A.S., Gagel'gans A.I.;
RT   "Low-molecular-weight peptides of venom of the giant hornet Vespa
RT   orientalis. Structure and function.";
RL   Biokhimiia 53:219-226(1988).
CC   -!- FUNCTION: Mast cell degranulating peptide. Activates G proteins that
CC       couple to phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Secreted. Target cell membrane. Note=Assumes an
CC       amphipathic alpha-helical conformation in a lipid environment. Forms a
CC       membrane channel in the prey (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   PIR; JN0389; JN0389.
DR   TCDB; 1.C.32.1.3; the amphipathic peptide mastoparan (mastoparan) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013213; Mastoparan.
DR   Pfam; PF08249; Mastoparan; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Mast cell degranulation; Membrane;
KW   Secreted; Target cell membrane; Target membrane.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan"
FT                   /id="PRO_0000044062"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   14 AA;  1494 MW;  C84F9ECA026B00DD CRC64;
     INLKAIAALV KKVL