MAST_VESTR
ID MAST_VESTR Reviewed; 14 AA.
AC P0C1Q7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 02-JUN-2021, entry version 20.
DE RecName: Full=Mastoparan-T;
OS Vespa tropica (Greater banded hornet) (Sphex tropica).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Vespinae; Vespa.
OX NCBI_TaxID=7450;
RN [1]
RP REVIEW.
RX PubMed=12759486; DOI=10.1159/000070431;
RA King T.P., Jim S.Y., Wittkowski K.M.;
RT "Inflammatory role of two venom components of yellow jackets (Vespula
RT vulgaris): a mast cell degranulating peptide mastoparan and phospholipase
RT A1.";
RL Int. Arch. Allergy Immunol. 131:25-32(2003).
CC -!- FUNCTION: Chemotactic peptide for polymorphonucleated leukocytes
CC (PMNL), but causing no hemolysis to erythrocytes and no mast cell
CC degranulation activity at physiological concentrations. Potent
CC antimicrobial peptide against Gram-positive and Gram-negative bacteria
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR InterPro; IPR013213; Mastoparan.
DR Pfam; PF08249; Mastoparan; 1.
PE 2: Evidence at transcript level;
KW Amidation; Antibiotic; Antimicrobial; Chemotaxis; Mast cell degranulation;
KW Secreted.
FT PEPTIDE 1..14
FT /note="Mastoparan-T"
FT /id="PRO_0000247266"
FT MOD_RES 14
FT /note="Leucine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 14 AA; 1514 MW; C85A7ECA1D75E0DD CRC64;
INLKAIAAFA KKLL