MATA1_CANAL
ID MATA1_CANAL Reviewed; 210 AA.
AC Q9UW23; A0A1D8PN95; Q59YH9;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Mating-type-like protein A1;
DE Short=MTLa1 protein;
GN Name=MTLA1; OrderedLocusNames=CAALFM_C501740CA; ORFNames=CaO19.3201;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN TRANSCRIPTIONAL
RP REPRESSION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=10455055; DOI=10.1126/science.285.5431.1271;
RA Hull C.M., Johnson A.D.;
RT "Identification of a mating type-like locus in the asexual pathogenic yeast
RT Candida albicans.";
RL Science 285:1271-1275(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP FUNCTION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=14622594; DOI=10.1016/s0092-8674(03)00885-7;
RA Tsong A.E., Miller M.G., Raisner R.M., Johnson A.D.;
RT "Evolution of a combinatorial transcriptional circuit: a case study in
RT yeasts.";
RL Cell 115:389-399(2003).
RN [6]
RP FUNCTION.
RX PubMed=12176317; DOI=10.1016/s0092-8674(02)00837-1;
RA Miller M.G., Johnson A.D.;
RT "White-opaque switching in Candida albicans is controlled by mating-type
RT locus homeodomain proteins and allows efficient mating.";
RL Cell 110:293-302(2002).
RN [7]
RP INDUCTION.
RX PubMed=15189997; DOI=10.1128/ec.3.3.764-775.2004;
RA Pendrak M.L., Yan S.S., Roberts D.D.;
RT "Hemoglobin regulates expression of an activator of mating-type locus alpha
RT genes in Candida albicans.";
RL Eukaryot. Cell 3:764-775(2004).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC Transcriptional corepressor that acts in conjunction with ALPHA2 to
CC repress transcription both of homozygote-specific genes and of genes
CC necessary for the white-opaque switch, a prerequisite for mating.
CC {ECO:0000269|PubMed:10455055, ECO:0000269|PubMed:12176317,
CC ECO:0000269|PubMed:14622594}.
CC -!- SUBUNIT: Forms a heterodimer with ALPHA2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- INDUCTION: Moderately repressed by HBR1 in response to hemoglobin and
CC growth signals. {ECO:0000269|PubMed:15189997}.
CC -!- MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in
CC addition to the genes for the regulatory proteins (MTLA1, MTLA2,
CC MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a
CC phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase
CC (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA
CC and OBPALPHA).
CC -!- MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL
CC locus and do not readily undergo white-opaque switching and mating, but
CC mating occurs in hemi- or homozygous strains. Mating takes place in
CC opaque cells, produces tetraploid progeny and seems to occur rarely, if
CC at all, in nature. Conservation of mating capacity is rather thought to
CC be due to the simultaneously regulated white-opaque switch, which seems
CC to play an important role in host commensalism.
CC -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
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DR EMBL; AF167162; AAD51404.1; -; Genomic_DNA.
DR EMBL; CP017627; AOW29605.1; -; Genomic_DNA.
DR RefSeq; XP_019330959.1; XM_019475414.1.
DR AlphaFoldDB; Q9UW23; -.
DR SMR; Q9UW23; -.
DR GeneID; 3643729; -.
DR KEGG; cal:CAALFM_C501740CA; -.
DR CGD; CAL0000200104; MTLA1.
DR VEuPathDB; FungiDB:C5_01740C_A; -.
DR HOGENOM; CLU_1669146_0_0_1; -.
DR InParanoid; Q9UW23; -.
DR OMA; QIRVWFT; -.
DR OrthoDB; 1594142at2759; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:CGD.
DR GO; GO:0031138; P:negative regulation of conjugation with cellular fusion; IMP:CGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0036166; P:phenotypic switching; IMP:CGD.
DR GO; GO:1900239; P:regulation of phenotypic switching; IMP:CGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..210
FT /note="Mating-type-like protein A1"
FT /id="PRO_0000049172"
FT DNA_BIND 141..200
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 54
FT /note="L -> F (in Ref. 1; AAD51404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 24712 MW; 5C29262F177BD4DC CRC64;
MNSEIESSLT LLKSVEKLVQ ATSVYKNEDN EEIFLQLKRE RQENSNSHEE TETLFHESLD
RLMKLSSIAG SKVQYELSLN NLYNLLLRTR KQEEEEAFIF PTVSTEEFAL EQITFEVSDQ
MDDDKDSEDD ILIKGEEIKK SKKKRQRLDN STKEFLEKVF EKNKQPNRRE RELIAEKHGV
SLSQIRVWFT NKRMRKKEPK SKAKSSSNST
