MATA1_CANGA
ID MATA1_CANGA Reviewed; 130 AA.
AC Q708A7; Q6FVP2;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Mating-type-like protein A1;
DE AltName: Full=MTL1a1 protein;
GN Name=MTL1A1;
GN and
GN Name=MTL2A1; OrderedLocusNames=CAGL0E00341g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=7549;
RX PubMed=12684382; DOI=10.1128/ec.2.2.328-340.2003;
RA Srikantha T., Lachke S.A., Soll D.R.;
RT "Three mating type-like loci in Candida glabrata.";
RL Eukaryot. Cell 2:328-340(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=14638801; DOI=10.1128/iai.71.12.7109-7118.2003;
RA Brockert P.J., Lachke S.A., Srikantha T., Pujol C., Galask R., Soll D.R.;
RT "Phenotypic switching and mating type switching of Candida glabrata at
RT sites of colonization.";
RL Infect. Immun. 71:7109-7118(2003).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Only present in a-cells (classes I and IV).
CC {ECO:0000269|PubMed:14638801}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC C.glabrata. MTL1 seems to be the expression locus that determines the
CC mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3
CC (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced
CC repositories of mating type information.
CC -!- MISCELLANEOUS: Haploid C.glabrata strains can switch mating type,
CC however, neither mating nor diploid forms of C.glabrata have been
CC observed so far.
CC -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE84398.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY191461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY191462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ617301; CAE84398.1; ALT_INIT; Genomic_DNA.
DR EMBL; CR380951; CAG58621.1; -; Genomic_DNA.
DR RefSeq; XP_445702.1; XM_445702.1.
DR AlphaFoldDB; Q708A7; -.
DR SMR; Q708A7; -.
DR EnsemblFungi; CAG58621; CAG58621; CAGL0E00341g.
DR GeneID; 2887541; -.
DR KEGG; cgr:CAGL0E00341g; -.
DR CGD; CAL0128822; MTL1a.
DR VEuPathDB; FungiDB:CAGL0E00341g; -.
DR HOGENOM; CLU_1937881_0_0_1; -.
DR InParanoid; Q708A7; -.
DR Proteomes; UP000002428; Chromosome E.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..130
FT /note="Mating-type-like protein A1"
FT /id="PRO_0000049174"
FT DNA_BIND 68..127
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 130 AA; 15433 MW; B0DA6DC6A3CD9A22 CRC64;
MMTVDPIQDL RNICLQILQS VNSNTLLEEE TWDYNTLINN IDLPKQTREA LRRSASQYLL
YCQRKNKTYT TRKPLPAKAK LQLVETFSKK RYLTRCEKHQ LAVQCGITTN QVQIWFANRR
KRSKDLNNRD
