ID   MATA1_KLUDE             Reviewed;         122 AA.
AC   Q708A1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Mating-type protein A1;
DE   AltName: Full=MATa1 transcription factor;
GN   Name=MATA1;
GN   and
GN   Name=HMRA1;
OS   Kluyveromyces delphensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=51657;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 2170;
RX   PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA   Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT   "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional corepressor that acts in conjunction with ALPHA2 to
CC       repress transcription of haploid-specific genes and of MATALPHA1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with ALPHA2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       K.delphensis. MAT is the expression locus that determines the mating
CC       type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and
CC       HMR (containing HMRA1) represent silenced repositories of mating type
CC       information. The mating type is determined by the MAT locus, which
CC       contains either a copy of HML or of HMR. Diploid cells are usually
CC       heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
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DR   EMBL; AJ617302; CAE84400.1; -; Genomic_DNA.
DR   EMBL; AJ617303; CAE84408.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q708A1; -.
DR   SMR; Q708A1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..122
FT                   /note="Mating-type protein A1"
FT                   /id="PRO_0000049177"
FT   DNA_BIND        62..121
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   122 AA;  14337 MW;  C280C8D487904DAD CRC64;
     MNVQEIHNIR EACITILSGT KHNSVLFEPC DKFDEVINSL DIDPDSKETL RRSVSLLVGT
     RNHKRGCNID KKTKDMLNKV YEQKQYLTKE EREFVAKKCN LTPLQVRVWF ANKRIRNKNT
     KM