MATA1_YARLL
ID MATA1_YARLL Reviewed; 176 AA.
AC Q707Y3; O93957;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Mating-type protein A1;
DE AltName: Full=MATA1 transcription factor;
GN Name=MATA1;
OS Yarrowia lipolytica (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=4952;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=10503550; DOI=10.1007/s004380051073;
RA Kurischko C., Schilhabel M.B., Kunze I., Franzl E.;
RT "The MATA locus of the dimorphic yeast Yarrowia lipolytica consists of two
RT divergently orientated genes.";
RL Mol. Gen. Genet. 262:180-188(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=1588911; DOI=10.1007/bf00266246;
RA Kurischko C., Fournier P., Chasles M., Weber H., Gaillardin C.;
RT "Cloning of the mating-type gene MATA of the yeast Yarrowia lipolytica.";
RL Mol. Gen. Genet. 232:423-426(1992).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC Transcriptional corepressor that acts in conjunction with ALPHA2 to
CC repress transcription of haploid-specific genes (By similarity).
CC Required for induction of sporulation in diploid cells. {ECO:0000250,
CC ECO:0000269|PubMed:10503550, ECO:0000269|PubMed:1588911}.
CC -!- SUBUNIT: Forms a heterodimer with ALPHA2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Only present in A-cells and in A/B diploid cells.
CC {ECO:0000269|PubMed:1588911}.
CC -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA07612.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ007708; CAA07612.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AJ617306; CAE84422.1; -; Genomic_DNA.
DR AlphaFoldDB; Q707Y3; -.
DR SMR; Q707Y3; -.
DR VEuPathDB; FungiDB:YALI1_C09885g; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..176
FT /note="Mating-type protein A1"
FT /id="PRO_0000049183"
FT DNA_BIND 88..147
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 141..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 176 AA; 20492 MW; E8D23A16FCE6BCD6 CRC64;
MPSRTPTDIW RCQRLILAAR KGETTCQALH EQSIEISSSL KWFEEISEWM SKFPESGLYI
STTIWTFLEG VPNEHRIKYD RLIRHYITYI QQLVPARLVT AYLDSLFKIC SHPTRTERRI
IGEHCGISLH QVTQWFTNRR FREPKTDSPD DGSTRFIPSP MTSPGSIDEC SFPESP
