ID   MATA2_CANAL             Reviewed;         201 AA.
AC   Q71U11; A0A1D8PN94; Q59YI0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Mating-type-like protein A2;
DE            Short=MTLa2 protein;
GN   Name=MTLA2; OrderedLocusNames=CAALFM_C501750CA; ORFNames=CaO19.3200;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=10455055; DOI=10.1126/science.285.5431.1271;
RA   Hull C.M., Johnson A.D.;
RT   "Identification of a mating type-like locus in the asexual pathogenic yeast
RT   Candida albicans.";
RL   Science 285:1271-1275(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [5]
RP   FUNCTION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=14622594; DOI=10.1016/s0092-8674(03)00885-7;
RA   Tsong A.E., Miller M.G., Raisner R.M., Johnson A.D.;
RT   "Evolution of a combinatorial transcriptional circuit: a case study in
RT   yeasts.";
RL   Cell 115:389-399(2003).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional activator that induces the transcription of a-specific
CC       mating genes. {ECO:0000269|PubMed:14622594}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in
CC       addition to the genes for the regulatory proteins (MTLA1, MTLA2,
CC       MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a
CC       phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase
CC       (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA
CC       and OBPALPHA).
CC   -!- MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL
CC       locus and do not readily undergo white-opaque switching and mating, but
CC       mating occurs in hemi- or homozygous strains. Mating takes place in
CC       opaque cells, produces tetraploid progeny and seems to occur rarely, if
CC       at all, in nature. Conservation of mating capacity is rather thought to
CC       be due to the simultaneously regulated white-opaque switch, which seems
CC       to play an important role in host commensalism.
CC   -!- SIMILARITY: Belongs to the MATA2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF167162; AAT08437.1; -; Genomic_DNA.
DR   EMBL; CP017627; AOW29606.1; -; Genomic_DNA.
DR   RefSeq; XP_019330960.1; XM_019475415.1.
DR   AlphaFoldDB; Q71U11; -.
DR   GeneID; 3643766; -.
DR   KEGG; cal:CAALFM_C501750CA; -.
DR   CGD; CAL0000185389; MTLA2.
DR   VEuPathDB; FungiDB:C5_01750C_A; -.
DR   HOGENOM; CLU_177145_0_0_1; -.
DR   InParanoid; Q71U11; -.
DR   OMA; DFLTHEN; -.
DR   OrthoDB; 1588869at2759; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:CGD.
DR   GO; GO:0007531; P:mating type determination; IMP:CGD.
DR   GO; GO:0007532; P:regulation of mating-type specific transcription, DNA-templated; TAS:CGD.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..201
FT                   /note="Mating-type-like protein A2"
FT                   /id="PRO_0000048581"
FT   DNA_BIND        56..122
FT                   /note="HMG box"
SQ   SEQUENCE   201 AA;  23358 MW;  5B6676E452627D33 CRC64;
     MPYTFNFPKS QSSFKYSIKS LTNSRSFPMI SIYVTPQSTP KFINNQSIDK MTVLSSFRSR
     NSFIIARSIL SKLLRKNKAD FKKVSKSVSL LWGSVDNSFK NYFEYLSILE SQWHDKKSSN
     LNPISSTRTT SELNYIELCS SIYNQSRKHP RSVQGNKAKF RLYKNVSKKS NRKPRRLKNG
     FKVSRSTINC SYGIYTEDVF Q