ID   MATA2_KLULA             Reviewed;         257 AA.
AC   Q9HG13; Q6CV59;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mating-type protein A2;
DE   AltName: Full=A2 HMG domain transcription factor;
GN   Name=MATA2; Synonyms=A2; OrderedLocusNames=KLLA0C03157g;
GN   and
GN   Name=HMRA2; OrderedLocusNames=KLLA0B14575g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10978277; DOI=10.1093/genetics/156.1.81;
RA   Aastroem S.U., Kegel A., Sjoestrand J.O.O., Rine J.;
RT   "Kluyveromyces lactis Sir2p regulates cation sensitivity and maintains a
RT   specialized chromatin structure at the cryptic alpha-locus.";
RL   Genetics 156:81-91(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA   Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT   "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional activator that induces the transcription of a-specific
CC       genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       K.lactis. MAT is the expression locus that determines the mating type
CC       of the cell, whereas HML (containing HMLALPHA1, HMLALPHA2 and
CC       HMLALPHA3) and HMR (containing HMRA1 and HMRA2) represent silenced
CC       repositories of mating type information. The mating type is determined
CC       by the MAT locus, which contains either a copy of HML or of HMR.
CC       Diploid cells are usually heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the MATA2 family. {ECO:0000305}.
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DR   EMBL; AF195067; AAG21093.1; -; Genomic_DNA.
DR   EMBL; AJ617304; CAE84410.1; -; Genomic_DNA.
DR   EMBL; CR382122; CAH02573.1; -; Genomic_DNA.
DR   EMBL; CR382123; CAH01189.1; -; Genomic_DNA.
DR   RefSeq; XP_452180.1; XM_452180.1.
DR   RefSeq; XP_452338.1; XM_452338.1.
DR   AlphaFoldDB; Q9HG13; -.
DR   EnsemblFungi; CAH01189; CAH01189; KLLA0_C03157g.
DR   EnsemblFungi; CAH02573; CAH02573; KLLA0_B14575g.
DR   GeneID; 2892068; -.
DR   GeneID; 2897386; -.
DR   KEGG; kla:KLLA0_B14575g; -.
DR   KEGG; kla:KLLA0_C03157g; -.
DR   eggNOG; ENOG502SG0V; Eukaryota.
DR   HOGENOM; CLU_1082067_0_0_1; -.
DR   InParanoid; Q9HG13; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..257
FT                   /note="Mating-type protein A2"
FT                   /id="PRO_0000048582"
FT   DNA_BIND        58..132
FT                   /note="HMG box"
FT   REGION          210..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  30205 MW;  63E5415500777450 CRC64;
     MANSTLRRTT FFKLTTTEDE DTIPKLLQPN NNSVAFPNLK RTGKAFTNDT IKENTKKYTR
     PRNQFVLMRT LFNRRVNNHI LQYYNKSKLE KKMFTLTSKI TSELWNESSP DLKSYFSLLA
     TLEENWHKYT HYCSWDRNSA QTLSMEPIEL SQVRPRLISS LTVGAGSSVS TYTLRELLLV
     RKIKSRKRKT TTLTQDSSPT TKFKYKFKKQ PKTKMNSNLS KLRFKSKQPP TPPEENSNVF
     KKRYTSENRI IEDLFLM