MATA2_YARLL
ID MATA2_YARLL Reviewed; 291 AA.
AC O93958;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Mating-type protein A2;
DE AltName: Full=MATA2 transcription factor;
GN Name=MATA2;
OS Yarrowia lipolytica (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=4952;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=10503550; DOI=10.1007/s004380051073;
RA Kurischko C., Schilhabel M.B., Kunze I., Franzl E.;
RT "The MATA locus of the dimorphic yeast Yarrowia lipolytica consists of two
RT divergently orientated genes.";
RL Mol. Gen. Genet. 262:180-188(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=ATCC 20460 / CBS 7504 / CLIB 89 / VTT C-10879 / W29 / IFP29;
RX PubMed=1588911; DOI=10.1007/bf00266246;
RA Kurischko C., Fournier P., Chasles M., Weber H., Gaillardin C.;
RT "Cloning of the mating-type gene MATA of the yeast Yarrowia lipolytica.";
RL Mol. Gen. Genet. 232:423-426(1992).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC Transcriptional activator that induces the transcription of A cell-
CC specific genes (By similarity). Required for repression of conjugation
CC in diploid cells. {ECO:0000250, ECO:0000269|PubMed:10503550,
CC ECO:0000269|PubMed:1588911}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Only present in A-cells and in A/B diploid cells.
CC {ECO:0000269|PubMed:1588911}.
CC -!- SIMILARITY: Belongs to the MATA2 family. {ECO:0000305}.
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DR EMBL; AJ007708; CAA07613.1; -; Genomic_DNA.
DR EMBL; AJ617306; CAE84423.1; -; Genomic_DNA.
DR AlphaFoldDB; O93958; -.
DR VEuPathDB; FungiDB:YALI1_C09878g; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Transcription; Transcription regulation.
FT CHAIN 1..291
FT /note="Mating-type protein A2"
FT /id="PRO_0000048583"
FT DNA_BIND 73..144
FT /note="HMG box"
FT REGION 148..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..173
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 291 AA; 33189 MW; 93D75AB806E52225 CRC64;
MENTILHIHS FQLPQTEQPY PEAMLFDRDT SDSRTVLTQK PNGLEISLNF LQYDGHKGLF
IRQDSRTNEP EYIEPKVLKP RNSYILFRNA TSRCSQSIDP NSAFVSRVSS YIWGSGIPNP
IVRRWFKYMG FFEALYHEVD YPEYIPNKLP KSPKKPKVQK GATKSKKKGA KGKNKVTALQ
VLVGPTVGVG GRMTVSPMTA FFSNNSHVTC YDPNFVLDTP TREFLMMPLD DITLPSQGPR
SDSQEQHVPR QPPDGQDYFD ILDIDDFVSP YDDLTTRSFT NRQLFKHATL G
