ID   MATA2_YEASX             Reviewed;         119 AA.
AC   P0CY12; D6VR97; P01367; P01368; Q6B184;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Putative mating-type protein A2;
DE            Short=MATa2 protein;
GN   Name=MATA2;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7034964; DOI=10.1016/0092-8674(81)90356-1;
RA   Astell C.R., Ahlstrom-Jonasson L., Smith M., Tatchell K., Nasmyth K.A.,
RA   Hall B.D.;
RT   "The sequence of the DNAs coding for the mating-type loci of Saccharomyces
RT   cerevisiae.";
RL   Cell 27:15-23(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7021055; DOI=10.1101/sqb.1981.045.01.113;
RA   Nasmyth K.A., Tatchell K., Hall B.D., Astell C., Smith M.;
RT   "Physical analysis of mating-type loci in Saccharomyces cerevisiae.";
RL   Cold Spring Harb. Symp. Quant. Biol. 45:961-981(1981).
RN   [3]
RP   FUNCTION.
RX   PubMed=2506439; DOI=10.1128/mcb.9.9.3992-3998.1989;
RA   Dranginis A.M.;
RT   "Regulation of STA1 gene expression by MAT during the life cycle of
RT   Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 9:3992-3998(1989).
CC   -!- FUNCTION: Probably not a functional protein. Cells lacking A2 show no
CC       obvious alterations in mating, sporulation and cell growth.
CC       {ECO:0000269|PubMed:2506439}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- MISCELLANEOUS: S.cerevisiae mating-type protein A2 is identical to
CC       residues 92-210 of ALPHA2 and should not be confused with the mating-
CC       type protein A2 of other yeast species.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       S.cerevisiae. MAT is the expression locus that determines the mating
CC       type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and
CC       HMR (containing HMRA1 and HMRA2) represent silenced repositories of
CC       mating type information. The mating type is determined by the MAT
CC       locus, which contains either a copy of HML or of HMR. Diploid cells are
CC       usually heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; V01313; CAA24620.1; -; Genomic_DNA.
DR   PIR; S19398; JFBYA2.
DR   AlphaFoldDB; P0CY12; -.
DR   SMR; P0CY12; -.
DR   IntAct; P0CY12; 1.
DR   MINT; P0CY12; -.
DR   SGD; S000029661; MATA2.
DR   VEuPathDB; FungiDB:YCR096C; -.
DR   PhylomeDB; P0CY12; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..119
FT                   /note="Putative mating-type protein A2"
FT                   /id="PRO_0000049185"
FT   DNA_BIND        38..100
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   119 AA;  13882 MW;  5616E6641D342092 CRC64;
     MRSIENDRSN YQLTQKNKSA DGLVFNVVTQ DMINKSTKPY RGHRFTKENV RILESWFAKN
     IENPYLDTKG LENLMKNTSL SRIQIKNWVS NRRRKEKTIT IAPELADLLS GEPLAKKKE