MATA_BPFR
ID MATA_BPFR Reviewed; 393 AA.
AC P15966;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Maturation protein A;
DE Short=MP;
DE AltName: Full=Assembly protein;
DE Short=A protein;
GN Name=A;
OS Enterobacteria phage fr (Bacteriophage fr).
OC Viruses; Riboviria; Orthornavirae; Lenarviricota; Leviviricetes;
OC Levivirales; Leviviridae; Levivirus.
OX NCBI_TaxID=12017;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2207135; DOI=10.1016/0167-4781(90)90149-v;
RA Adhin M.R., Avots A.J., Berzin V.M., Overbeek G.P., van Duin J.;
RT "Complete nucleotide sequence of the group I RNA bacteriophage fr.";
RL Biochim. Biophys. Acta 1050:104-109(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3628010; DOI=10.1093/nar/15.16.6741;
RA Berzin V.M., Avots A.J., Jansone I.V., Gintnere L., Tsimanis A.J.;
RT "Sequence of the genes coding for the A-protein and coat protein of
RT bacteriophage fr.";
RL Nucleic Acids Res. 15:6741-6741(1987).
CC -!- FUNCTION: The maturation protein is required for the typical attachment
CC of the phage to the side of the bacterial pili. Binds to sequences
CC located toward each end of the genome, hence circularizing it. The RNA
CC genome-maturation protein A complex is released from the capsid upon
CC host receptor binding. Maturation protein A enters the cell along with
CC the viral RNA. {ECO:0000250|UniProtKB:P03610}.
CC -!- SUBUNIT: Interacts with the host pilus. {ECO:0000250|UniProtKB:P03610}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P03610}. Note=A
CC single copy of the maturation protein is present in the virion.
CC {ECO:0000250|UniProtKB:P03610}.
CC -!- PTM: During internalization, MP is proteolytically cleaved into two
CC fragments allowing translation and replication to start.
CC {ECO:0000250|UniProtKB:P03610}.
CC -!- SIMILARITY: Belongs to the Levivirus maturation protein family.
CC {ECO:0000305}.
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DR EMBL; X15031; CAA33135.1; -; mRNA.
DR EMBL; M31635; AAA32188.1; -; Genomic_RNA.
DR PIR; S08017; S08017.
DR SMR; P15966; -.
DR Proteomes; UP000002582; Genome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0099009; P:viral genome circularization; IEA:UniProtKB-KW.
DR GO; GO:0039666; P:virion attachment to host cell pilus; IEA:UniProtKB-KW.
DR InterPro; IPR005563; A_protein.
DR Pfam; PF03863; Phage_mat-A; 1.
PE 2: Evidence at transcript level;
KW Host-virus interaction; Reference proteome; RNA-binding;
KW Viral attachment to host cell; Viral attachment to host cell pilus;
KW Viral genome circularization; Viral penetration into host cytoplasm;
KW Virion; Virus entry into host cell.
FT CHAIN 1..393
FT /note="Maturation protein A"
FT /id="PRO_0000164857"
FT REGION 26..233
FT /note="Viral RNA-binding"
FT /evidence="ECO:0000250|UniProtKB:P03610"
FT CONFLICT 232
FT /note="R -> S (in Ref. 2; AAA32188)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="T -> I (in Ref. 2; AAA32188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 43956 MW; 9CD23BE75FE1459F CRC64;
MRKFIPTERM SKSHVVSVRE YADGELEDNS LPLIYRSNWS PGQYTSTGPR TKEWHYPSSY
SRGAIGIKAL DQGKYARLGT SWGREFEERA GYGMSIDARS CYSLFPVSQN LTWIDVPTNV
ANRATTEVLG KVTQGNFNLG VALAEARSTA SQLSTQTIAL IKAYTAARRG NWRQALRYLA
LNENRKFNSK SVASRWLELQ FGWMPLLSDI QGAYEMLTKV HLKAFMPMRA VRQVGQNVSL
SGRLTSPAAS YKSTCNISRR IVIWFYINDA RLAWLSSLGI LNPLGIVWEK VPFSFLVDWL
LPVGNMLEGL TAPIGCSYQS GTVTDVISGE STITADDIYG WDTVRPATAK VQISAVHRGV
QSVWPTTGVY VKSPFSMVHT LDALALFRQR LWK