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MATA_BPFR
ID   MATA_BPFR               Reviewed;         393 AA.
AC   P15966;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Maturation protein A;
DE            Short=MP;
DE   AltName: Full=Assembly protein;
DE            Short=A protein;
GN   Name=A;
OS   Enterobacteria phage fr (Bacteriophage fr).
OC   Viruses; Riboviria; Orthornavirae; Lenarviricota; Leviviricetes;
OC   Levivirales; Leviviridae; Levivirus.
OX   NCBI_TaxID=12017;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2207135; DOI=10.1016/0167-4781(90)90149-v;
RA   Adhin M.R., Avots A.J., Berzin V.M., Overbeek G.P., van Duin J.;
RT   "Complete nucleotide sequence of the group I RNA bacteriophage fr.";
RL   Biochim. Biophys. Acta 1050:104-109(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3628010; DOI=10.1093/nar/15.16.6741;
RA   Berzin V.M., Avots A.J., Jansone I.V., Gintnere L., Tsimanis A.J.;
RT   "Sequence of the genes coding for the A-protein and coat protein of
RT   bacteriophage fr.";
RL   Nucleic Acids Res. 15:6741-6741(1987).
CC   -!- FUNCTION: The maturation protein is required for the typical attachment
CC       of the phage to the side of the bacterial pili. Binds to sequences
CC       located toward each end of the genome, hence circularizing it. The RNA
CC       genome-maturation protein A complex is released from the capsid upon
CC       host receptor binding. Maturation protein A enters the cell along with
CC       the viral RNA. {ECO:0000250|UniProtKB:P03610}.
CC   -!- SUBUNIT: Interacts with the host pilus. {ECO:0000250|UniProtKB:P03610}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P03610}. Note=A
CC       single copy of the maturation protein is present in the virion.
CC       {ECO:0000250|UniProtKB:P03610}.
CC   -!- PTM: During internalization, MP is proteolytically cleaved into two
CC       fragments allowing translation and replication to start.
CC       {ECO:0000250|UniProtKB:P03610}.
CC   -!- SIMILARITY: Belongs to the Levivirus maturation protein family.
CC       {ECO:0000305}.
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DR   EMBL; X15031; CAA33135.1; -; mRNA.
DR   EMBL; M31635; AAA32188.1; -; Genomic_RNA.
DR   PIR; S08017; S08017.
DR   SMR; P15966; -.
DR   Proteomes; UP000002582; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099009; P:viral genome circularization; IEA:UniProtKB-KW.
DR   GO; GO:0039666; P:virion attachment to host cell pilus; IEA:UniProtKB-KW.
DR   InterPro; IPR005563; A_protein.
DR   Pfam; PF03863; Phage_mat-A; 1.
PE   2: Evidence at transcript level;
KW   Host-virus interaction; Reference proteome; RNA-binding;
KW   Viral attachment to host cell; Viral attachment to host cell pilus;
KW   Viral genome circularization; Viral penetration into host cytoplasm;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..393
FT                   /note="Maturation protein A"
FT                   /id="PRO_0000164857"
FT   REGION          26..233
FT                   /note="Viral RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P03610"
FT   CONFLICT        232
FT                   /note="R -> S (in Ref. 2; AAA32188)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        334
FT                   /note="T -> I (in Ref. 2; AAA32188)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   393 AA;  43956 MW;  9CD23BE75FE1459F CRC64;
     MRKFIPTERM SKSHVVSVRE YADGELEDNS LPLIYRSNWS PGQYTSTGPR TKEWHYPSSY
     SRGAIGIKAL DQGKYARLGT SWGREFEERA GYGMSIDARS CYSLFPVSQN LTWIDVPTNV
     ANRATTEVLG KVTQGNFNLG VALAEARSTA SQLSTQTIAL IKAYTAARRG NWRQALRYLA
     LNENRKFNSK SVASRWLELQ FGWMPLLSDI QGAYEMLTKV HLKAFMPMRA VRQVGQNVSL
     SGRLTSPAAS YKSTCNISRR IVIWFYINDA RLAWLSSLGI LNPLGIVWEK VPFSFLVDWL
     LPVGNMLEGL TAPIGCSYQS GTVTDVISGE STITADDIYG WDTVRPATAK VQISAVHRGV
     QSVWPTTGVY VKSPFSMVHT LDALALFRQR LWK
 
 
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