ID   MATA_NEUCR              Reviewed;         293 AA.
AC   P19392; Q7RVK1; V5IQ53;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Mating-type protein A-1;
DE            Short=Mt A-1;
GN   Name=mtA-1; Synonyms=matA-1; ORFNames=NCU01958;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=2142303; DOI=10.1073/pnas.87.13.4912;
RA   Glass N.L., Grotelueschen J., Metzenberg R.L.;
RT   "Neurospora crassa A mating-type region.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:4912-4916(1990).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=8628238; DOI=10.1007/bf02172989;
RA   Ferreira A.V.-B., Saupe S., Glass N.L.;
RT   "Transcriptional analysis of the mtA idiomorph of Neurospora crassa
RT   identifies two genes in addition to mtA-1.";
RL   Mol. Gen. Genet. 250:767-774(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [4]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=8569681; DOI=10.1007/bf02191831;
RA   Saupe S., Stenberg L., Shiu K.T., Griffiths A.J.F., Glass N.L.;
RT   "The molecular nature of mutations in the mt A-1 gene of the Neurospora
RT   crassa A idiomorph and their relation to mating-type function.";
RL   Mol. Gen. Genet. 250:115-122(1996).
RN   [5]
RP   FUNCTION IN TRANSCRIPTIONAL ACTIVATION.
RX   PubMed=12139624; DOI=10.1046/j.1365-2958.2002.03052.x;
RA   Bobrowicz P., Pawlak R., Correa A., Bell-Pedersen D., Ebbole D.J.;
RT   "The Neurospora crassa pheromone precursor genes are regulated by the
RT   mating type locus and the circadian clock.";
RL   Mol. Microbiol. 45:795-804(2002).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional activator that induces the transcription of A-specific
CC       genes like mating factor ccg-4. Required for mating as an A-cell and
CC       for blocking of heterokaryon formation (vegetative incompatibility).
CC       {ECO:0000269|PubMed:12139624, ECO:0000269|PubMed:8569681}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}.
CC   -!- DEVELOPMENTAL STAGE: Only present in A-cells and in a/A diploid cells.
CC       {ECO:0000269|PubMed:8569681}.
CC   -!- SIMILARITY: Belongs to the MATALPHA1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00655}.
CC   -!- CAUTION: Do not confuse Mt a-1 with MT A-1; these are two different
CC       proteins. {ECO:0000305}.
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DR   EMBL; M33876; AAC37478.1; -; Genomic_DNA.
DR   EMBL; CM002236; ESA43845.1; -; Genomic_DNA.
DR   PIR; S65582; S65582.
DR   RefSeq; XP_011392909.1; XM_011394607.1.
DR   AlphaFoldDB; P19392; -.
DR   STRING; 5141.EFNCRP00000001088; -.
DR   EnsemblFungi; ESA43845; ESA43845; NCU01958.
DR   GeneID; 3880391; -.
DR   KEGG; ncr:NCU01958; -.
DR   VEuPathDB; FungiDB:NCU01958; -.
DR   HOGENOM; CLU_080756_0_0_1; -.
DR   InParanoid; P19392; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IEA:InterPro.
DR   GO; GO:0045895; P:positive regulation of mating-type specific transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR006856; MATalpha_HMGbox.
DR   Pfam; PF04769; MATalpha_HMGbox; 1.
DR   PROSITE; PS51325; ALPHA_BOX; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..293
FT                   /note="Mating-type protein A-1"
FT                   /id="PRO_0000206019"
FT   DNA_BIND        42..97
FT                   /note="Alpha box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00655"
SQ   SEQUENCE   293 AA;  33179 MW;  F6C486B145DF8689 CRC64;
     MSGVDQIVKT FADLAEDDRE AAMRAFSRMM RRGTEPVRRI PAAKKKVNGF MGFRSYYSPL
     FSQLPQKERS PFMTILWQHD PFHNEWDFMC SVYSSIRTYL EQEKVTLQLW IHYAVGHLGV
     IIRDNYMASF GWNLVRFPNG THDLERTALP LVQHNLQPMN GLCLLTKCLE SGLPLANPHS
     VIAKLSDPSY DMIWFNKRPH RQQGHAVQTD ESEVGVSAMF PRNHTVAAEV DGIINLPLSH
     WIQQGEFGTE SGYSAQFETL LDSILENGHA SSNDPYNMAL AIDVPMMGFN GGA