MATC_NEUCR
ID MATC_NEUCR Reviewed; 373 AA.
AC Q10115; Q7SE99;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Mating-type protein A-2;
DE Short=Mt A-2;
GN Name=matA-2; Synonyms=mtA-2; ORFNames=NCU01959;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=8628238; DOI=10.1007/bf02172989;
RA Ferreira A.V.-B., Saupe S., Glass N.L.;
RT "Transcriptional analysis of the mtA idiomorph of Neurospora crassa
RT identifies two genes in addition to mtA-1.";
RL Mol. Gen. Genet. 250:767-774(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [3]
RP FUNCTION.
RX PubMed=9539425; DOI=10.1093/genetics/148.3.1069;
RA Ferreira A.V.-B., An Z., Metzenberg R.L., Glass N.L.;
RT "Characterization of mat A-2, mat A-3 and deltamatA mating-type mutants of
RT Neurospora crassa.";
RL Genetics 148:1069-1079(1998).
CC -!- FUNCTION: Required, together with mating-type protein A-3, for
CC efficient ascospore formation. {ECO:0000269|PubMed:9539425}.
CC -!- DEVELOPMENTAL STAGE: Only present in A-cells and in a/A diploid cells.
CC {ECO:0000269|PubMed:8628238}.
CC -!- SIMILARITY: To P.anserina SMR1. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC37477.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=EAA35087.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M33876; AAC37477.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CM002236; EAA35087.3; ALT_INIT; Genomic_DNA.
DR PIR; S65583; S65583.
DR RefSeq; XP_964323.3; XM_959230.3.
DR AlphaFoldDB; Q10115; -.
DR STRING; 5141.EFNCRP00000001033; -.
DR EnsemblFungi; EAA35087; EAA35087; NCU01959.
DR GeneID; 3880488; -.
DR KEGG; ncr:NCU01959; -.
DR HOGENOM; CLU_771993_0_0_1; -.
DR InParanoid; Q10115; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR InterPro; IPR031472; MAT1-1-2/MatA-2/Smr1.
DR Pfam; PF17043; MAT1-1-2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..373
FT /note="Mating-type protein A-2"
FT /id="PRO_0000096245"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 56
FT /note="F -> N (in Ref. 1; AAC37477)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="H -> Y (in Ref. 1; AAC37477)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 42763 MW; 6EB9E0ECD1EBF965 CRC64;
MNLLNMQPKR SEQPAMFEEN RASSQEGQDL EVMYKKLHQL QARLSRSVLS EAIKEFEENL
RCLFHEAKLL LCSTRTKYRQ SWFGSSNEFG SSDERRIIKT SCCIIESTNT ILNFLSFLEK
NRGLPFGGDQ RLQQAAYKGQ QFAFRLLRSL TLHKAAQEVP GKDFGLVYGK DVYVLNGHIL
HRSKQEIVGQ AGGRNWHVDH TLHPLRRVPG TPWHKFFGNL EVGDDKQLRL FDDDAAVDSY
RVGPQKFFVV IPETAEFILD EVSSEHQRVA TIHTENGHVQ PPAPTSIQQE ALLRKLDFAM
TTSLPGYVVE GQPEIVFHHE GLRQIPVDYS QERPLSILSH VFTRPALWGE GLELADHFDP
RDGVQQEEHI YYI