ID   MATD_NEUCR              Reviewed;         324 AA.
AC   Q10116; Q7SE98;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Mating-type protein A-3;
DE            Short=Mt A-3;
GN   Name=mtA-3; ORFNames=NCU01960;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=8628238; DOI=10.1007/bf02172989;
RA   Ferreira A.V.-B., Saupe S., Glass N.L.;
RT   "Transcriptional analysis of the mtA idiomorph of Neurospora crassa
RT   identifies two genes in addition to mtA-1.";
RL   Mol. Gen. Genet. 250:767-774(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=9539425; DOI=10.1093/genetics/148.3.1069;
RA   Ferreira A.V.-B., An Z., Metzenberg R.L., Glass N.L.;
RT   "Characterization of mat A-2, mat A-3 and deltamatA mating-type mutants of
RT   Neurospora crassa.";
RL   Genetics 148:1069-1079(1998).
CC   -!- FUNCTION: Required, together with mating-type protein A-2, for
CC       efficient ascospore formation. {ECO:0000269|PubMed:9539425}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DEVELOPMENTAL STAGE: Only present in A-cells and in a/A diploid cells.
CC       {ECO:0000269|PubMed:8628238}.
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DR   EMBL; M33876; AAC37476.1; -; Genomic_DNA.
DR   EMBL; CM002236; EAA35088.1; -; Genomic_DNA.
DR   PIR; S65584; S65584.
DR   RefSeq; XP_964324.1; XM_959231.2.
DR   AlphaFoldDB; Q10116; -.
DR   STRING; 5141.EFNCRP00000001043; -.
DR   EnsemblFungi; EAA35088; EAA35088; NCU01960.
DR   GeneID; 3880489; -.
DR   KEGG; ncr:NCU01960; -.
DR   VEuPathDB; FungiDB:NCU01960; -.
DR   HOGENOM; CLU_858146_0_0_1; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..324
FT                   /note="Mating-type protein A-3"
FT                   /id="PRO_0000048589"
FT   DNA_BIND        147..215
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   324 AA;  36539 MW;  415F361D38A25982 CRC64;
     MSALDVDSIS DIAPGLSPVT AIHYGRIQVM LFRSHLAEFA EEDLVYAMDN SVVVFGEEAL
     LMVAPDESSI AICTYPFGLM MMEWGNWDIL AVSPPSRTPT IPSESVLGIS NQGGANVEQQ
     EQSSHTIDMT LPSNFFEQSS VTQSNGTSRP RNQFVLYYQW LLDTLFSEDP SLSARNISQI
     VAGLWNSEHP AAKARFRELA EMEVHRHRAE NPHLYPDQPR FPTTDPVPPR MRYPCVISPE
     DRQRILRMLD FVWEESNGQL AAEEAALNDV VQPQQAEEVG PFPDFEWEEP NHIIDMSTDL
     SVAQDPDFMM TEDDSMRFLL KQAS