ARGL1_MOUSE
ID ARGL1_MOUSE Reviewed; 271 AA.
AC Q3UL36; Q80XJ0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Arginine and glutamate-rich protein 1;
GN Name=Arglu1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-190.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UL36-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UL36-2; Sequence=VSP_025675, VSP_025676;
CC -!- SIMILARITY: Belongs to the UPF0430 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE26615.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
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DR EMBL; AC138368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046971; AAH46971.1; -; mRNA.
DR EMBL; AK145733; BAE26615.1; ALT_SEQ; mRNA.
DR CCDS; CCDS40215.1; -. [Q3UL36-1]
DR RefSeq; NP_789819.2; NM_176849.3. [Q3UL36-1]
DR AlphaFoldDB; Q3UL36; -.
DR SMR; Q3UL36; -.
DR BioGRID; 231486; 4.
DR IntAct; Q3UL36; 150.
DR MINT; Q3UL36; -.
DR STRING; 10090.ENSMUSP00000039493; -.
DR iPTMnet; Q3UL36; -.
DR PhosphoSitePlus; Q3UL36; -.
DR EPD; Q3UL36; -.
DR jPOST; Q3UL36; -.
DR MaxQB; Q3UL36; -.
DR PaxDb; Q3UL36; -.
DR PeptideAtlas; Q3UL36; -.
DR PRIDE; Q3UL36; -.
DR ProteomicsDB; 265079; -. [Q3UL36-1]
DR ProteomicsDB; 265080; -. [Q3UL36-2]
DR Antibodypedia; 25410; 86 antibodies from 20 providers.
DR Ensembl; ENSMUST00000048545; ENSMUSP00000039493; ENSMUSG00000040459. [Q3UL36-1]
DR GeneID; 234023; -.
DR KEGG; mmu:234023; -.
DR UCSC; uc009kug.1; mouse. [Q3UL36-1]
DR CTD; 55082; -.
DR MGI; MGI:2442985; Arglu1.
DR VEuPathDB; HostDB:ENSMUSG00000040459; -.
DR eggNOG; ENOG502QPR5; Eukaryota.
DR GeneTree; ENSGT00730000111249; -.
DR HOGENOM; CLU_076749_0_0_1; -.
DR InParanoid; Q3UL36; -.
DR OMA; YRHSPTI; -.
DR PhylomeDB; Q3UL36; -.
DR TreeFam; TF324123; -.
DR BioGRID-ORCS; 234023; 18 hits in 73 CRISPR screens.
DR ChiTaRS; Arglu1; mouse.
DR PRO; PR:Q3UL36; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3UL36; protein.
DR Bgee; ENSMUSG00000040459; Expressed in renal corpuscle and 263 other tissues.
DR ExpressionAtlas; Q3UL36; baseline and differential.
DR Genevisible; Q3UL36; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR033371; ARGLU1.
DR PANTHER; PTHR31711; PTHR31711; 1.
DR Pfam; PF15346; ARGLU; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..271
FT /note="Arginine and glutamate-rich protein 1"
FT /id="PRO_0000288439"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..55
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWB6"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWB6"
FT MOD_RES 61
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWB6"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWB6"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT MOD_RES 264
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWB6"
FT VAR_SEQ 52..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025675"
FT VAR_SEQ 190..271
FT /note="EEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQE
FT RQRQQKEEQKIILGKGKSRPKLSFSLKTQD -> VTLGRLESRDSPWQNFQCQVCLLLS
FT PERDGMRLS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025676"
SQ SEQUENCE 271 AA; 32887 MW; A17012F236A37340 CRC64;
MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR RRESRSRSRS
TNAAASRRER ERASSPPDRI DIFGRTVSKR SSLDEKQKRE EEEKKAEFER QRKIRQQEIE
EKLIEEETAR RVEELVAKRV EEELEKRKDE IEREVLRRVE EAKRIMEKQL LEELERQRQA
ELAAQKAREE EERAKREELE RILEENNRKI AEAQAKLAEE QLRIVEEQRK IHEERMKLEQ
ERQRQQKEEQ KIILGKGKSR PKLSFSLKTQ D
