ID   ARGO_ECOL6              Reviewed;         211 AA.
AC   Q8FE55;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN   Name=argO {ECO:0000255|HAMAP-Rule:MF_01901}; OrderedLocusNames=c3501;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in the export of arginine. Important to control the
CC       intracellular level of arginine and the correct balance between
CC       arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC         ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01901}.
CC   -!- INDUCTION: Transcriptionally regulated by ArgP. Lysine has a negative
CC       effect on the expression of argO (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01901, ECO:0000305}.
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DR   EMBL; AE014075; AAN81949.1; -; Genomic_DNA.
DR   RefSeq; WP_000493346.1; NC_004431.1.
DR   AlphaFoldDB; Q8FE55; -.
DR   STRING; 199310.c3501; -.
DR   EnsemblBacteria; AAN81949; AAN81949; c3501.
DR   GeneID; 58460585; -.
DR   KEGG; ecc:c3501; -.
DR   eggNOG; COG1279; Bacteria.
DR   HOGENOM; CLU_087840_0_1_6; -.
DR   OMA; FARPRAW; -.
DR   BioCyc; ECOL199310:C3501-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01901; ArgO; 1.
DR   InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..211
FT                   /note="Arginine exporter protein ArgO"
FT                   /id="PRO_0000204160"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ   SEQUENCE   211 AA;  23174 MW;  5F22D06A3A8FBD73 CRC64;
     MFSYYFQGLA LGAAMILPLG PQNAFVMNQG IRRQYHIMIA LLCAISDLVL ICAGIFGGSA
     LLMQSPWLLA LVTWGGVAFL LWYGFGAFKT AMSSNIELAS AEVLKQGRWK IIATMLAVTW
     LNPHVYLDTF VVLGSLGGQL DVEPKRWFAL GTISASFLWF FGLAILAAWL APRLRTAKSQ
     RIINLVVGCV MWFIALQLAR DGIAHAQALF S