ARGO_KLEP3
ID ARGO_KLEP3 Reviewed; 211 AA.
AC B5XUC1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN Name=argO {ECO:0000255|HAMAP-Rule:MF_01901}; OrderedLocusNames=KPK_0747;
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342;
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- FUNCTION: Involved in the export of arginine. Important to control the
CC intracellular level of arginine and the correct balance between
CC arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01901}.
CC -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC {ECO:0000255|HAMAP-Rule:MF_01901}.
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DR EMBL; CP000964; ACI10727.1; -; Genomic_DNA.
DR AlphaFoldDB; B5XUC1; -.
DR EnsemblBacteria; ACI10727; ACI10727; KPK_0747.
DR KEGG; kpe:KPK_0747; -.
DR HOGENOM; CLU_087840_0_1_6; -.
DR OMA; FARPRAW; -.
DR OrthoDB; 1953934at2; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR HAMAP; MF_01901; ArgO; 1.
DR InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR InterPro; IPR001123; LeuE-type.
DR InterPro; IPR004777; Lys/arg_exporter.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR TIGRFAMs; TIGR00948; 2a75; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..211
FT /note="Arginine exporter protein ArgO"
FT /id="PRO_1000188717"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ SEQUENCE 211 AA; 23191 MW; AF036BDF8EF46DD5 CRC64;
MFTYYFQGLA LGAAMILPLG PQNAFVMNQG IRRQYHLMIA LLCAVSDLLL ICAGIFGGSA
LLMQSPWLLA IVTWGGVAFL LWYGFGALKT AFSQNLELAS AEVMQQGRWK IIITMLAVTW
LNPHVYLDTF VVLGSLGGQL AVEPKRWFAL GTISASFLWF FGLALLAAWL APRLRTAKAQ
RIINIVVGAV MWFIAFQLAK EGVGHILALL N