MATMC_SCHPM
ID MATMC_SCHPM Reviewed; 181 AA.
AC C7U331; P10840; Q9URE7;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Mating-type M-specific polypeptide Mc;
DE Short=mat-Mc;
GN Name=mat3-Mc; Synonyms=matMc; ORFNames=SPMTR.04;
OS Schizosaccharomyces pombe (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=4896;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC STRAIN=h90;
RX PubMed=2900761; DOI=10.1002/j.1460-2075.1988.tb02973.x;
RA Kelly M., Burke J., Smith M., Klar A., Beach D.;
RT "Four mating-type genes control sexual differentiation in the fission
RT yeast.";
RL EMBO J. 7:1537-1547(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=h90;
RG The Schizosaccharomyces pombe Genome Sequencing Consortium;
RA Wood V.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-181, AND FUNCTION.
RX PubMed=8227043; DOI=10.1016/s0021-9258(19)74537-2;
RA Dooijes D., van de Wetering M., Knippels L., Clevers H.;
RT "The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-
RT specific DNA-binding high mobility group box protein.";
RL J. Biol. Chem. 268:24813-24817(1993).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion. Positive
CC regulator of MFM genes. The HMG box recognizes the DNA sequence 5'-
CC AACAAAG-3'. Required for conjugation and efficient meiosis.
CC {ECO:0000269|PubMed:2900761, ECO:0000269|PubMed:8227043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC body {ECO:0000250}.
CC -!- INDUCTION: By nitrogen starvation. {ECO:0000269|PubMed:2900761}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the
CC alternate allele present in mat1, either P (plus) in a h+ or M (minus)
CC in a h- cell. Mat2-P and mat3-M serve as donor of information that is
CC transposed to mat1 during a switch of mating type.
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DR EMBL; X07642; CAA30481.1; -; Genomic_DNA.
DR EMBL; FP565355; CBB12357.1; -; Genomic_DNA.
DR RefSeq; NP_595867.1; NM_001021773.2.
DR RefSeq; NP_595875.1; NM_001021781.1.
DR AlphaFoldDB; C7U331; -.
DR SMR; C7U331; -.
DR EnsemblFungi; SPBC1711.02.1; SPBC1711.02.1:pep; SPBC1711.02.
DR EnsemblFungi; SPBC23G7.09.1; SPBC23G7.09.1:pep; SPBC23G7.09.
DR EnsemblFungi; SPMTR.04.1; SPMTR.04.1:pep; SPMTR.04.
DR GeneID; 2539619; -.
DR GeneID; 2540048; -.
DR KEGG; spo:SPBC1711.02; -.
DR KEGG; spo:SPBC23G7.09; -.
DR PomBase; SPMTR.04; mat3-Mc.
DR VEuPathDB; FungiDB:SPBC1711.02; -.
DR HOGENOM; CLU_128900_0_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; DNA-binding; Nucleus; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..181
FT /note="Mating-type M-specific polypeptide Mc"
FT /id="PRO_0000410975"
FT DNA_BIND 103..171
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT CONFLICT 174
FT /note="Missing (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 181 AA; 21003 MW; 9301E076FB12016F CRC64;
MDSHQELSAG SPISYDFLDP DWCFKRYLTK DALHSIETGK GAAYFVPDGF TPILIPNSQS
YLLDGNSAQL PRPQPISFTL DQCKVPGYIL KSLRKDTTST ERTPRPPNAF ILYRKEKHAT
LLKSNPSINN SQVSKLVGEM WRNESKEVRM RYFKMSEFYK AQHQKMYPGY KYQPRKNKVK
R
