ID   ARGO_SALPK              Reviewed;         211 AA.
AC   B5BFN1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN   Name=argO {ECO:0000255|HAMAP-Rule:MF_01901}; OrderedLocusNames=SSPA2736;
OS   Salmonella paratyphi A (strain AKU_12601).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=554290;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AKU_12601;
RX   PubMed=19159446; DOI=10.1186/1471-2164-10-36;
RA   Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A.,
RA   Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N.,
RA   Mungall K., Dougan G., Parkhill J.;
RT   "Pseudogene accumulation in the evolutionary histories of Salmonella
RT   enterica serovars Paratyphi A and Typhi.";
RL   BMC Genomics 10:36-36(2009).
CC   -!- FUNCTION: Involved in the export of arginine. Important to control the
CC       intracellular level of arginine and the correct balance between
CC       arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC         ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01901}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01901}.
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DR   EMBL; FM200053; CAR60977.1; -; Genomic_DNA.
DR   RefSeq; WP_000626872.1; NC_011147.1.
DR   AlphaFoldDB; B5BFN1; -.
DR   KEGG; sek:SSPA2736; -.
DR   HOGENOM; CLU_087840_0_1_6; -.
DR   OMA; FARPRAW; -.
DR   Proteomes; UP000001869; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01901; ArgO; 1.
DR   InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..211
FT                   /note="Arginine exporter protein ArgO"
FT                   /id="PRO_1000188724"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ   SEQUENCE   211 AA;  23248 MW;  75F211F1290D9B8B CRC64;
     MISYYFQGFA LGVAMILPLG PQNAFVMNQG IRRQYHLMIA LLCALSDLVL ISAGIFGGSA
     LLMQSPWLLA LVTWGGVAFL LWYGFGALKT AMSSNLELAS AEVMKQGRWK IIATMLAVTW
     LNPHVYLDTF VVLGSLGGQL AMEPKRWFAL GTISASFLWF FGLALLAAWL APRLRTAKAQ
     RIINILVGVV MWLIAFQLAR EGVAHMHALF N