MATMC_SCHPO
ID MATMC_SCHPO Reviewed; 181 AA.
AC P0CY17; P10840; Q9URE7;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Mating-type M-specific polypeptide Mc;
DE Short=mat-Mc;
GN Name=mat1-Mc; Synonyms=matMc; ORFNames=SPBC23G7.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (MATMCA AND MATMCB).
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=2900761; DOI=10.1002/j.1460-2075.1988.tb02973.x;
RA Kelly M., Burke J., Smith M., Klar A., Beach D.;
RT "Four mating-type genes control sexual differentiation in the fission
RT yeast.";
RL EMBO J. 7:1537-1547(1988).
RN [3]
RP FUNCTION.
RX PubMed=8227043; DOI=10.1016/s0021-9258(19)74537-2;
RA Dooijes D., van de Wetering M., Knippels L., Clevers H.;
RT "The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-
RT specific DNA-binding high mobility group box protein.";
RL J. Biol. Chem. 268:24813-24817(1993).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion. Positive
CC regulator of MFM genes. The HMG box recognizes the DNA sequence 5'-
CC AACAAAG-3'. Required for conjugation and efficient meiosis.
CC {ECO:0000269|PubMed:2900761, ECO:0000269|PubMed:8227043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
CC -!- INDUCTION: By nitrogen starvation. {ECO:0000269|PubMed:2900761}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the
CC alternate allele present in mat1, either P (plus) in a h+ or M (minus)
CC in a h- cell. Mat2-P and mat3-M serve as donor of information that is
CC transposed to mat1 during a switch of mating type.
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DR EMBL; CU329671; CAA22625.1; -; Genomic_DNA.
DR PIR; S00555; S00555.
DR RefSeq; NP_595867.1; NM_001021773.2.
DR RefSeq; NP_595875.1; NM_001021781.1.
DR AlphaFoldDB; P0CY17; -.
DR SMR; P0CY17; -.
DR BioGRID; 276177; 1.
DR BioGRID; 276586; 1.
DR STRING; 4896.SPBC1711.02.1; -.
DR PaxDb; P0CY17; -.
DR EnsemblFungi; SPBC1711.02.1; SPBC1711.02.1:pep; SPBC1711.02.
DR EnsemblFungi; SPBC23G7.09.1; SPBC23G7.09.1:pep; SPBC23G7.09.
DR EnsemblFungi; SPMTR.04.1; SPMTR.04.1:pep; SPMTR.04.
DR GeneID; 2539619; -.
DR GeneID; 2540048; -.
DR KEGG; spo:SPBC1711.02; -.
DR KEGG; spo:SPBC23G7.09; -.
DR PomBase; SPBC23G7.09; mat1-Mc.
DR VEuPathDB; FungiDB:SPBC1711.02; -.
DR VEuPathDB; FungiDB:SPBC23G7.09; -.
DR VEuPathDB; FungiDB:SPMTR.04; -.
DR eggNOG; KOG0527; Eukaryota.
DR HOGENOM; CLU_128900_0_0_1; -.
DR InParanoid; P0CY17; -.
DR PhylomeDB; P0CY17; -.
DR PRO; PR:P0CY17; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:PomBase.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0044377; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending; IDA:PomBase.
DR GO; GO:0044374; F:sequence-specific DNA binding, bending; IDA:PomBase.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:PomBase.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0010514; P:induction of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:0007531; P:mating type determination; NAS:PomBase.
DR GO; GO:1900237; P:positive regulation of induction of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:0051446; P:positive regulation of meiotic cell cycle; IMP:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; DNA-binding; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..181
FT /note="Mating-type M-specific polypeptide Mc"
FT /id="PRO_0000410974"
FT DNA_BIND 103..171
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ SEQUENCE 181 AA; 21003 MW; 9301E076FB12016F CRC64;
MDSHQELSAG SPISYDFLDP DWCFKRYLTK DALHSIETGK GAAYFVPDGF TPILIPNSQS
YLLDGNSAQL PRPQPISFTL DQCKVPGYIL KSLRKDTTST ERTPRPPNAF ILYRKEKHAT
LLKSNPSINN SQVSKLVGEM WRNESKEVRM RYFKMSEFYK AQHQKMYPGY KYQPRKNKVK
R
