ID   MATPI_SCHPM             Reviewed;         159 AA.
AC   P10842; C7U329;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Mating-type P-specific polypeptide Pi;
GN   Name=mat2-Pi; Synonyms=matPi; ORFNames=SPMTR.02;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=h90;
RX   PubMed=2900761; DOI=10.1002/j.1460-2075.1988.tb02973.x;
RA   Kelly M., Burke J., Smith M., Klar A., Beach D.;
RT   "Four mating-type genes control sexual differentiation in the fission
RT   yeast.";
RL   EMBO J. 7:1537-1547(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=h90;
RG   The Schizosaccharomyces pombe Genome Sequencing Consortium;
RA   Wood V.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion. Required
CC       for meiosis, but plays no role in conjugation.
CC       {ECO:0000269|PubMed:2900761}.
CC   -!- INTERACTION:
CC       P10842; P0CY15: mat1-Mi; Xeno; NbExp=2; IntAct=EBI-20725367, EBI-20725384;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- INDUCTION: By nitrogen starvation. {ECO:0000269|PubMed:2900761}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       S.pombe, mat1, mat2-P and mat3-M. Cell type is determined by the
CC       alternate allele present in mat1, either P (plus) in a h+ or M (minus)
CC       in a h- cell. Mat2-P and mat3-M serve as donor of information that is
CC       transposed to mat1 during a switch of mating type.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; X07643; CAA30483.1; -; Genomic_DNA.
DR   EMBL; FP565355; CBB12355.1; -; Genomic_DNA.
DR   PIR; S00556; S00556.
DR   AlphaFoldDB; P10842; -.
DR   SMR; P10842; -.
DR   IntAct; P10842; 1.
DR   EnsemblFungi; SPMTR.02.1; SPMTR.02.1:pep; SPMTR.02.
DR   PomBase; SPMTR.02; mat2-Pi.
DR   VEuPathDB; FungiDB:SPMTR.02; -.
DR   HOGENOM; CLU_1653147_0_0_1; -.
DR   OMA; TINYERF; -.
DR   GO; GO:0000785; C:chromatin; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; EXP:PomBase.
DR   GO; GO:0062071; C:Pi Mi complex; EXP:PomBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:PomBase.
DR   GO; GO:0071444; P:cellular response to pheromone; IMP:PomBase.
DR   GO; GO:0007531; P:mating type determination; NAS:PomBase.
DR   GO; GO:0140538; P:negative regulation of conjugation with zygote; IMP:PomBase.
DR   GO; GO:0051446; P:positive regulation of meiotic cell cycle; IMP:PomBase.
DR   GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IDA:PomBase.
DR   GO; GO:0034504; P:protein localization to nucleus; IMP:PomBase.
DR   GO; GO:0110044; P:regulation of cell cycle switching, mitotic to meiotic cell cycle; IDA:PomBase.
DR   GO; GO:0110046; P:signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle; IMP:PomBase.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Stress response.
FT   CHAIN           1..159
FT                   /note="Mating-type P-specific polypeptide Pi"
FT                   /id="PRO_0000049409"
FT   DNA_BIND        103..159
FT                   /note="Homeobox; TALE-type; partial"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   159 AA;  18671 MW;  226371B0446AE8EA CRC64;
     MKRVAVLLKT VMCEFLKCDY NGYDRIISLL RRILTLICTP NLNGLTIKRV IDSMQSLEYI
     KQTCNFKLQM CISSMAFKRN NALQNCNHYA WCDDHCSDIG RPMTTVRGQC SKCTKPHLMR
     WLLLHYDNPY PSNSEFYDLS AATGLTRTQL RNWFSNRRR