ID   ARGO_SHIFL              Reviewed;         211 AA.
AC   Q7UBP8; Q83JT7;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN   Name=argO {ECO:0000255|HAMAP-Rule:MF_01901};
GN   OrderedLocusNames=SF2908, S3108;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Involved in the export of arginine. Important to control the
CC       intracellular level of arginine and the correct balance between
CC       arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC         ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01901}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01901, ECO:0000305}.
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DR   EMBL; AE005674; AAN44390.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18212.1; -; Genomic_DNA.
DR   RefSeq; NP_708683.2; NC_004337.2.
DR   RefSeq; WP_000493360.1; NZ_UIQL01000025.1.
DR   AlphaFoldDB; Q7UBP8; -.
DR   STRING; 198214.SF2908; -.
DR   EnsemblBacteria; AAN44390; AAN44390; SF2908.
DR   EnsemblBacteria; AAP18212; AAP18212; S3108.
DR   GeneID; 1025919; -.
DR   GeneID; 66673200; -.
DR   KEGG; sfl:SF2908; -.
DR   KEGG; sfx:S3108; -.
DR   PATRIC; fig|198214.7.peg.3459; -.
DR   HOGENOM; CLU_087840_0_1_6; -.
DR   OMA; FARPRAW; -.
DR   OrthoDB; 1953934at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01901; ArgO; 1.
DR   InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..211
FT                   /note="Arginine exporter protein ArgO"
FT                   /id="PRO_0000204167"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ   SEQUENCE   211 AA;  23202 MW;  4422D078B182266C CRC64;
     MFSYYFQGLA LGAAMILPLG PQNAFVMNQG IRRQYHIMIA LLCAISDLVL ICAGIFGGSA
     LLMQSPWLLA LVTWGGVVFL LWYGFGAFKT AMSSNIELAS AEVLKQGRWK IIATMLAVTW
     LNPHVYLDTF VVLGSLGGQL DVEPKRWFAL GTISASFLWF FGLAILAAWL APRLRTAKSQ
     RIINLVVGCV MWFIALQLAR DGIAHAQALF S