ARGO_YERPE
ID ARGO_YERPE Reviewed; 205 AA.
AC Q8ZHH6; Q0WIC2; Q7CGS7;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN Name=argO {ECO:0000255|HAMAP-Rule:MF_01901};
GN OrderedLocusNames=YPO0918, y3305, YP_3522;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in the export of arginine. Important to control the
CC intracellular level of arginine and the correct balance between
CC arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01901}.
CC -!- MISCELLANEOUS: In Yersinia pestis biovar Mediaevails str. 91001, the
CC CDS has been disrupted by IS100 element.
CC -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC {ECO:0000255|HAMAP-Rule:MF_01901, ECO:0000305}.
CC -!- CAUTION: PubMed:15368893 (AE017042) sequence differs from that shown
CC due to the presence of an IS100 insertion sequence. This gene in strain
CC 91001 is probably a pseudogene. {ECO:0000305}.
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DR EMBL; AL590842; CAL19585.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86855.1; -; Genomic_DNA.
DR EMBL; AE017042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; AG0112; AG0112.
DR RefSeq; WP_002209960.1; NZ_WUCM01000038.1.
DR RefSeq; YP_002345966.1; NC_003143.1.
DR AlphaFoldDB; Q8ZHH6; -.
DR STRING; 214092.YPO0918; -.
DR PaxDb; Q8ZHH6; -.
DR DNASU; 1148252; -.
DR EnsemblBacteria; AAM86855; AAM86855; y3305.
DR GeneID; 66844376; -.
DR KEGG; ype:YPO0918; -.
DR KEGG; ypk:y3305; -.
DR PATRIC; fig|214092.21.peg.1193; -.
DR eggNOG; COG1279; Bacteria.
DR HOGENOM; CLU_087840_0_1_6; -.
DR OMA; FARPRAW; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR HAMAP; MF_01901; ArgO; 1.
DR InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR InterPro; IPR001123; LeuE-type.
DR InterPro; IPR004777; Lys/arg_exporter.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR TIGRFAMs; TIGR00948; 2a75; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..205
FT /note="Arginine exporter protein ArgO"
FT /id="PRO_0000204168"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ SEQUENCE 205 AA; 22164 MW; 2969524391474CDA CRC64;
MLAVYLHGFI LSAAMILPLG PQNVFVMNQG IKRQHHLMSA SLCALSDIIL ICAGIFGGSA
LLSRSPLLLA LVTWGGVAFL MWYGWGALMA AWRGDGVASS ATSVTQGRWR ILVTLLAVTW
LNPHVYLDTF VVLGSLGGQL LPDIRPWFAL GAVTASIVWF FALALLAAWL SPWLNRPVAQ
RIINLFVGGV MGFIAFQLAR QGFGL
