ID   MATRX_BDVV              Reviewed;         142 AA.
AC   P0C795; P52637;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   29-SEP-2021, entry version 32.
DE   RecName: Full=Matrix protein;
DE   AltName: Full=gp18;
DE   AltName: Full=p16;
GN   Name=M;
OS   Borna disease virus (strain V) (BDV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Bornaviridae; unclassified Bornaviridae.
OX   NCBI_TaxID=928296;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9352; Bradypodidae (three-fingered sloths).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=9850; Cervidae (deer).
OH   NCBI_TaxID=109474; Crocidura leucodon (Bicoloured white-toothed shrew) (Celebes shrew).
OH   NCBI_TaxID=9788; Equidae (horses).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=56798; Hexaprotodon liberiensis (Pygmy hippopotamus) (Choeropsis liberiensis).
OH   NCBI_TaxID=9844; Lama glama (Llama).
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
OH   NCBI_TaxID=8801; Struthio camelus (Common ostrich).
OH   NCBI_TaxID=9455; Varecia variegata (Black-and-white ruffed lemur) (Lemur variegatus).
OH   NCBI_TaxID=30538; Vicugna pacos (Alpaca) (Lama pacos).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8183914; DOI=10.1073/pnas.91.10.4362;
RA   Briese T., Schneemann A., Lewis A.J., Park Y.-S., Kim S., Ludwig H.,
RA   Lipkin W.I.;
RT   "Genomic organization of Borna disease virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:4362-4366(1994).
RN   [2]
RP   REVIEW.
RX   PubMed=11815287; DOI=10.2741/a789;
RA   Ikuta K., Ibrahim M.S., Kobayashi T., Tomonaga K.;
RT   "Borna disease virus and infection in humans.";
RL   Front. Biosci. 7:470-495(2002).
RN   [3]
RP   SUBUNIT.
RX   PubMed=15862310; DOI=10.1016/j.febslet.2005.04.002;
RA   Kraus I., Bogner E., Lilie H., Eickmann M., Garten W.;
RT   "Oligomerization and assembly of the matrix protein of Borna disease
RT   virus.";
RL   FEBS Lett. 579:2686-2692(2005).
RN   [4]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH PHOSPHOPROTEIN.
RX   PubMed=17079312; DOI=10.1128/jvi.01351-06;
RA   Chase G., Mayer D., Hildebrand A., Frank R., Hayashi Y., Tomonaga K.,
RA   Schwemmle M.;
RT   "Borna disease virus matrix protein is an integral component of the viral
RT   ribonucleoprotein complex that does not interfere with polymerase
RT   activity.";
RL   J. Virol. 81:743-749(2007).
CC   -!- FUNCTION: Plays a crucial role in virion assembly and budding.
CC       {ECO:0000305}.
CC   -!- SUBUNIT: Homooligomer (PubMed:15862310). Forms homotetramers (By
CC       similarity). Interacts with phosphoprotein P (PubMed:17079312). Binds
CC       to ssRNA (By similarity). {ECO:0000250|UniProtKB:P0C794,
CC       ECO:0000269|PubMed:15862310, ECO:0000269|PubMed:17079312}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm
CC       {ECO:0000269|PubMed:17079312}. Host cell membrane; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P0C794}. Host nucleus
CC       {ECO:0000269|PubMed:17079312}. Note=During viral budding, associates
CC       with the inner side of the plasma membrane of infected cells (By
CC       similarity). Found in nuclear punctate structures that have been
CC       proposed to be the sites of viral replication and transcription, also
CC       termed viral speckles of transcripts (vSPOTs).
CC       {ECO:0000250|UniProtKB:P0C794, ECO:0000269|PubMed:17079312}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Matrix protein;
CC         IsoId=P0C795-1; Sequence=Displayed;
CC       Name=Envelope glycoprotein p57 precursor;
CC         IsoId=P52638-1; Sequence=External;
CC       Name=Large structural protein;
CC         IsoId=P52639-1; Sequence=External;
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DR   EMBL; U04608; AAA20226.1; -; Genomic_RNA.
DR   RefSeq; NP_042022.1; NC_001607.1.
DR   SMR; P0C795; -.
DR   GeneID; 26799165; -.
DR   KEGG; vg:26799165; -.
DR   Proteomes; UP000007804; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.20.40; -; 1.
DR   InterPro; IPR032414; BDV_M.
DR   InterPro; IPR038520; BDV_M_sf.
DR   Pfam; PF16520; BDV_M; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Host cell membrane; Host cytoplasm; Host membrane;
KW   Host nucleus; Membrane; Reference proteome; RNA-binding;
KW   Viral matrix protein; Virion.
FT   CHAIN           1..142
FT                   /note="Matrix protein"
FT                   /id="PRO_0000405345"
SQ   SEQUENCE   142 AA;  16244 MW;  5EE3B3DA094F771D CRC64;
     MNSKHSYVEL KDKVIVPGWP TLMLEIDFVG GTSRNQFLNI PFLSVKEPLQ LPREKKLTDY
     FTIDVEPAGH SLVNIYFQID DFLLLTLNSL SVYKDPIRKY MFLRLNKDQS KHAINAAFNV
     FSYRLRNIGV GPLGPDIRSS GP