ID   MATRX_LBV               Reviewed;         202 AA.
AC   Q6JAM6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 64.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Lagos bat virus (LBV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Lyssavirus.
OX   NCBI_TaxID=38766;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Nigeria/8619/1958;
RX   PubMed=15163747; DOI=10.1128/jvi.78.12.6543-6555.2004;
RA   Kassis R., Larrous F., Estaquier J., Bourhy H.;
RT   "Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism
RT   involving caspase-8 activation.";
RL   J. Virol. 78:6543-6555(2004).
CC   -!- FUNCTION: Plays a major role in assembly and budding of virion.
CC       Completely covers the ribonucleoprotein coil and keep it in condensed
CC       bullet-shaped form. Inhibits viral transcription and stimulates
CC       replication. Plays a major role in early induction of TRAIL-mediated
CC       apoptosis in infected neurons (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Interacts with nucleoprotein and with the
CC       cytoplasmic domain of glycoprotein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane protein.
CC       Host endomembrane system {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY
CC       motif which potentially interacts with the WW domain 3 of NEDD4 E3
CC       ubiquitin ligase (Potential). {ECO:0000305}.
CC   -!- MISCELLANEOUS: Most abundant protein in the virion. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lyssavirus matrix protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY540349; AAT06782.1; -; mRNA.
DR   PDB; 2W2S; X-ray; 2.75 A; A=1-202.
DR   PDBsum; 2W2S; -.
DR   SMR; Q6JAM6; -.
DR   EvolutionaryTrace; Q6JAM6; -.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.460.20; -; 1.
DR   InterPro; IPR006870; Rhabdo_M.
DR   InterPro; IPR038617; Rhabdovirus_M_sf.
DR   Pfam; PF04785; Rhabdo_M2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Apoptosis; Host membrane; Host-virus interaction; Membrane;
KW   Viral budding; Viral budding via the host ESCRT complexes;
KW   Viral envelope protein; Viral matrix protein; Viral release from host cell;
KW   Virion.
FT   CHAIN           1..202
FT                   /note="Matrix protein"
FT                   /id="PRO_0000299104"
FT   REGION          13..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           35..38
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000255"
FT   STRAND          49..62
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   HELIX           69..76
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   HELIX           77..81
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   HELIX           87..89
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   HELIX           90..101
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          106..108
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          111..124
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          136..146
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          149..161
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   HELIX           175..183
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          188..190
FT                   /evidence="ECO:0007829|PDB:2W2S"
FT   STRAND          198..200
FT                   /evidence="ECO:0007829|PDB:2W2S"
SQ   SEQUENCE   202 AA;  23152 MW;  498402DD591D3A19 CRC64;
     MNFLRKIVKN CKDEEIPKPG TPSAPPDDDD LWMPPPEYVP LTQIKGKENV RNFCINGEIK
     ICSPNGYSFR ILRHILKSFD NVYSGNRRLI GVVKVVIGLV LSASPVPEGM NWVYKLRRTL
     IFQWAESHGP LEGEELEYSQ EITWDDEAEF VSLQIRVSAK QCHIQGRLWC INMNSKACQL
     WADMGLKTQQ SQEDENTSLL LE