ID   MATRX_MEASE             Reviewed;         335 AA.
AC   P06942;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 67.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis
OS   virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Morbillivirus.
OX   NCBI_TaxID=11235;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3754588; DOI=10.1128/jvi.58.2.408-416.1986;
RA   Bellini W.J., Englund G., Richardson C.D., Rozenblatt S., Lazzarini R.A.;
RT   "Matrix genes of measles virus and canine distemper virus: cloning,
RT   nucleotide sequences, and deduced amino acid sequences.";
RL   J. Virol. 58:408-416(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2596022; DOI=10.1016/0042-6822(89)90554-0;
RA   Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Baczko K., Meulen V.,
RA   Pardowitz J., Flanagan S., Rima B.K., Udem S.A.;
RT   "Mutated and hypermutated genes of persistent measles viruses which caused
RT   lethal human brain diseases.";
RL   Virology 173:415-425(1989).
CC   -!- FUNCTION: The M protein has a crucial role in virus assembly and
CC       interacts with the RNP complex as well as with the viral membrane.
CC   -!- SUBUNIT: Interacts with host ANP32B. {ECO:0000250|UniProtKB:Q9W850}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the morbillivirus/respirovirus/rubulavirus M
CC       protein family. {ECO:0000305}.
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DR   EMBL; M12668; AAA66616.1; -; Genomic_RNA.
DR   EMBL; K01711; AAA75497.1; -; Genomic_RNA.
DR   PIR; A93018; MFNZMV.
DR   SMR; P06942; -.
DR   Proteomes; UP000000833; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0019013; C:viral nucleocapsid; IDA:CACAO.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0019068; P:virion assembly; IEA:InterPro.
DR   Gene3D; 2.70.20.50; -; 1.
DR   Gene3D; 2.70.20.60; -; 1.
DR   InterPro; IPR000982; Matrix.
DR   InterPro; IPR042539; Matrix_C.
DR   InterPro; IPR042540; Matrix_N.
DR   Pfam; PF00661; Matrix; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome; Viral envelope protein;
KW   Viral matrix protein; Virion.
FT   CHAIN           1..335
FT                   /note="Matrix protein"
FT                   /id="PRO_0000142752"
SQ   SEQUENCE   335 AA;  37714 MW;  A14CBD88A00A7F17 CRC64;
     MTEIYDFDKS AWDIKGSIAP IQPTTYSDGR LVPQVRVIDP GLGDRKDECF MYMFLLGVVE
     DSDPLGPPIG RAFGSLPLGV GRSTAKPEKL LKEATELDIV VRRTAGLNEK LVFYNNTPLT
     LLTPWRKVLT TGSVFNANQV CSAVNLIPLD TPQRFRVVYM SITRLSDNGY YTVPRRMLEF
     RSVNAVAFNL LVTLRIDKAI GPGKIIDNTE QLPEATFMVH IGNFRRKKSE VYSADYCKMK
     IEKMGLVFAL GGIGGTSLHI RSTGKMSKTL HAQLGFKKTL CYPLMDINED LNRLLWRSRC
     KIVRIQAVLQ PSVPQEFRIY DDVIINDDQG LFKVL