ID   MATRX_MOKV              Reviewed;         202 AA.
AC   P0C571;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   29-SEP-2021, entry version 55.
DE   RecName: Full=Matrix protein;
DE   AltName: Full=Phosphoprotein M2;
GN   Name=M;
OS   Mokola virus (MOKV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Lyssavirus.
OX   NCBI_TaxID=12538;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=269271; Chodsigoa caovansunga (Van Sung's shrew).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9989; Rodentia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9225031; DOI=10.1099/0022-1317-78-7-1571;
RA   Le Mercier P., Jacob Y., Tordo N.;
RT   "The complete Mokola virus genome sequence: structure of the RNA-dependent
RT   RNA polymerase.";
RL   J. Gen. Virol. 78:1571-1576(1997).
RN   [2]
RP   APOPTOSIS.
RX   PubMed=15163747; DOI=10.1128/jvi.78.12.6543-6555.2004;
RA   Kassis R., Larrous F., Estaquier J., Bourhy H.;
RT   "Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism
RT   involving caspase-8 activation.";
RL   J. Virol. 78:6543-6555(2004).
CC   -!- FUNCTION: Plays a major role in assembly and budding of virion.
CC       Completely covers the ribonucleoprotein coil and keep it in condensed
CC       bullet-shaped form. Inhibits viral transcription and stimulates
CC       replication. Plays a major role in early induction of TRAIL-mediated
CC       apoptosis in infected neurons (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Interacts with nucleoprotein and with the
CC       cytoplasmic domain of glycoprotein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane protein.
CC       Host endomembrane system {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY
CC       motif which potentially interacts with the WW domain 3 of NEDD4 E3
CC       ubiquitin ligase (Potential). {ECO:0000305}.
CC   -!- MISCELLANEOUS: Most abundant protein in the virion. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lyssavirus matrix protein family.
CC       {ECO:0000305}.
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DR   EMBL; Y09762; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   RefSeq; YP_142352.1; NC_006429.1.
DR   SMR; P0C571; -.
DR   GeneID; 3159475; -.
DR   KEGG; vg:3159475; -.
DR   Proteomes; UP000006826; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.460.20; -; 1.
DR   InterPro; IPR006870; Rhabdo_M.
DR   InterPro; IPR038617; Rhabdovirus_M_sf.
DR   Pfam; PF04785; Rhabdo_M2; 1.
PE   3: Inferred from homology;
KW   Host membrane; Host-virus interaction; Membrane; Phosphoprotein;
KW   Reference proteome; Viral budding;
KW   Viral budding via the host ESCRT complexes; Viral envelope protein;
KW   Viral matrix protein; Viral release from host cell; Virion.
FT   CHAIN           1..202
FT                   /note="Matrix protein"
FT                   /id="PRO_0000295572"
FT   REGION          115..151
FT                   /note="Essential for glycoprotein binding"
FT                   /evidence="ECO:0000250"
FT   MOTIF           35..38
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  23100 MW;  B3B583A2CF7948DC CRC64;
     MNFLKKMIKS CKDEETQKYP SASAPPDDDD IWMPPPEYVP LTQVKGKASV RNFCISGEVK
     ICSPNGYSFK ILRHILKSFD NVYSGNRRMI GLVKVVIGLV LSGSPVPEGM NWVYKLRRTL
     IFQWAESHGP LEGEELEYSQ EITWDDEAEF VGLQIRVSAR QCHIQGRLWC INMNSRACQL
     WADMILQTQQ SPDDENTSLL LE