ARGO_YERPS
ID ARGO_YERPS Reviewed; 205 AA.
AC Q666Q4;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Arginine exporter protein ArgO {ECO:0000255|HAMAP-Rule:MF_01901};
GN Name=argO {ECO:0000255|HAMAP-Rule:MF_01901}; OrderedLocusNames=YPTB3193;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Involved in the export of arginine. Important to control the
CC intracellular level of arginine and the correct balance between
CC arginine and lysine. {ECO:0000255|HAMAP-Rule:MF_01901}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32144;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01901};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01901}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01901}.
CC -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC {ECO:0000255|HAMAP-Rule:MF_01901}.
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DR EMBL; BX936398; CAH22431.1; -; Genomic_DNA.
DR RefSeq; WP_002209960.1; NZ_CP009712.1.
DR AlphaFoldDB; Q666Q4; -.
DR EnsemblBacteria; CAH22431; CAH22431; YPTB3193.
DR GeneID; 66844376; -.
DR KEGG; ypo:BZ17_3418; -.
DR KEGG; yps:YPTB3193; -.
DR PATRIC; fig|273123.14.peg.3587; -.
DR OMA; FARPRAW; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:InterPro.
DR HAMAP; MF_01901; ArgO; 1.
DR InterPro; IPR023445; Arg_export_ArgO_enterobac.
DR InterPro; IPR001123; LeuE-type.
DR InterPro; IPR004777; Lys/arg_exporter.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR TIGRFAMs; TIGR00948; 2a75; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..205
FT /note="Arginine exporter protein ArgO"
FT /id="PRO_0000204169"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01901"
SQ SEQUENCE 205 AA; 22164 MW; 2969524391474CDA CRC64;
MLAVYLHGFI LSAAMILPLG PQNVFVMNQG IKRQHHLMSA SLCALSDIIL ICAGIFGGSA
LLSRSPLLLA LVTWGGVAFL MWYGWGALMA AWRGDGVASS ATSVTQGRWR ILVTLLAVTW
LNPHVYLDTF VVLGSLGGQL LPDIRPWFAL GAVTASIVWF FALALLAAWL SPWLNRPVAQ
RIINLFVGGV MGFIAFQLAR QGFGL
