ID   MATRX_NDVB              Reviewed;         364 AA.
AC   P06157;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   07-APR-2021, entry version 67.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Newcastle disease virus (strain Beaudette C/45) (NDV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Avulavirinae;
OC   Orthoavulavirus; Avian orthoavulavirus 1.
OX   NCBI_TaxID=11178;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3786143; DOI=10.1093/nar/14.22.9051;
RA   Chambers P., Millar N.S., Platt S.G., Emmerson P.T.;
RT   "Nucleotide sequence of the gene encoding the matrix protein of Newcastle
RT   disease virus.";
RL   Nucleic Acids Res. 14:9051-9061(1986).
CC   -!- FUNCTION: The M protein has a crucial role in virus assembly and
CC       interacts with the RNP complex as well as with the viral membrane.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. The matrix protein contains one L domain: a
CC       FPIV motif (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the morbillivirus/respirovirus/rubulavirus M
CC       protein family. {ECO:0000305}.
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DR   EMBL; X04687; CAA28389.1; -; Genomic_RNA.
DR   PIR; A26111; MFNZNC.
DR   SMR; P06157; -.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.20.50; -; 1.
DR   Gene3D; 2.70.20.60; -; 1.
DR   InterPro; IPR000982; Matrix.
DR   InterPro; IPR042539; Matrix_C.
DR   InterPro; IPR042540; Matrix_N.
DR   Pfam; PF00661; Matrix; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Viral budding;
KW   Viral budding via the host ESCRT complexes; Viral envelope protein;
KW   Viral matrix protein; Viral release from host cell; Virion.
FT   CHAIN           1..364
FT                   /note="Matrix protein"
FT                   /id="PRO_0000142760"
FT   MOTIF           23..26
FT                   /note="FPIV motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   364 AA;  39605 MW;  214C35E23CA2E81A CRC64;
     MDSSRTIGLY FDSAHSSSNL LAFPIVLQDT GDGKKQIAPQ YRIQRLDSWT DSKEDSVFIT
     TYGFIFQVGN EEATVGMIND NPKRELLSAA MLCLGSVPNT GDLVELARAC LTMVVTCKKS
     ATNTERMVFS VVQAPQVLQS CRVVANKYSS VNAVKHVKAP EKIPGSGTLE YKVNFVSLTV
     VPKKDVYKIP TAVLKVSGSS LYNLALNVTI NVEVDSRSPL VKSLSKSDSG YYANLFLHIG
     LMTTVDRRGK KVTFDKLEKK IRSLDLSVGL SDVLGPSVLV KARGARTKLL APFFSSSGTA
     CYPIANASPQ VAKILWSQTA CLRSVKIIIQ AGTQRTVAVT ADHEVTSTKL EKGHTLAKYN
     PFKK