ID   MATRX_PI2HT             Reviewed;         377 AA.
AC   P24266;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   07-APR-2021, entry version 78.
DE   RecName: Full=Matrix protein;
DE   AltName: Full=Membrane protein;
GN   Name=M;
OS   Human parainfluenza 2 virus (strain Toshiba) (HPIV-2).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Human parainfluenza 2 virus.
OX   NCBI_TaxID=11214;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2173264; DOI=10.1016/0042-6822(90)90155-k;
RA   Kawano M., Bando H., Ohgimoto S., Okamoto K., Kondo K., Tsurudome M.,
RA   Nishio M., Ito Y.;
RT   "Complete nucleotide sequence of the matrix gene of human parainfluenza
RT   type 2 virus and expression of the M protein in bacteria.";
RL   Virology 179:857-861(1990).
CC   -!- FUNCTION: The M protein has a crucial role in virus assembly and
CC       interacts with the RNP complex as well as with the viral membrane.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the morbillivirus/respirovirus/rubulavirus M
CC       protein family. {ECO:0000305}.
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DR   EMBL; M62734; AAA46862.1; -; mRNA.
DR   EMBL; X57559; CAA40785.1; -; Genomic_DNA.
DR   PIR; A36421; MFNZP2.
DR   SMR; P24266; -.
DR   Proteomes; UP000000472; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0019068; P:virion assembly; IEA:InterPro.
DR   Gene3D; 2.70.20.50; -; 1.
DR   Gene3D; 2.70.20.60; -; 1.
DR   InterPro; IPR000982; Matrix.
DR   InterPro; IPR042539; Matrix_C.
DR   InterPro; IPR042540; Matrix_N.
DR   Pfam; PF00661; Matrix; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..377
FT                   /note="Matrix protein"
FT                   /id="PRO_0000142764"
SQ   SEQUENCE   377 AA;  42312 MW;  A181A79C55276736 CRC64;
     MPIISLPADP TSPSQSLTPF PIQLDTKDGK AGKLLKQIRI RYLNEPNSRH TPITFINTYG
     FVYARDTSGG IHSEISSDLA AGSITACMMK LGPGPNIQNA NLVLRSLNEF YVKVKKTSSQ
     REEAVFELVN IPTLLREHAL CKRKMLVCSA EKFLKNPSKL QAGFEYVYIP TFVSITYSPR
     NLNYQVARPI LKFRSRFVYS IHLELILRLL CKSDSPLMKS YNADRTGRGC LASVWIHVCN
     ILKNKSIKQQ GRESYFIAKC MSMQLQVSIA DLWGPTIIIK SLGHIPKTAL PFFSKDGIAC
     HPLQDVSPNL AKSLWSVGCE IESAKLILQE SDLNELMGHQ DLITDKIAIR SGQRTFERSK
     FSPFKKYASI PNLEAIN