ID   MATRX_PI3H4             Reviewed;         353 AA.
AC   P07873;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human
OS   parainfluenza 3 virus (strain NIH 47885)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Respirovirus.
OX   NCBI_TaxID=11217;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3027966; DOI=10.1016/0042-6822(87)90453-3;
RA   Luk D., Masters P.S., Sanchez A., Banerjee A.K.;
RT   "Complete nucleotide sequence of the matrix protein mRNA and three
RT   intergenic junctions of human parainfluenza virus type 3.";
RL   Virology 156:189-192(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3029963; DOI=10.1016/0042-6822(87)90309-6;
RA   Galinski M.S., Mink M.A., Lambert D.M., Wechsler S.L., Pons M.W.;
RT   "Molecular cloning and sequence analysis of the human parainfluenza 3 virus
RT   gene encoding the matrix protein.";
RL   Virology 157:24-30(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2883252; DOI=10.1099/0022-1317-68-5-1491;
RA   Spriggs M.K., Johnson P.R., Collins P.L.;
RT   "Sequence analysis of the matrix protein gene of human parainfluenza virus
RT   type 3: extensive sequence homology among paramyxoviruses.";
RL   J. Gen. Virol. 68:1491-1497(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3031622; DOI=10.1093/nar/15.7.3182;
RA   Prinoski K., Cote M.J., Kang C.Y., Dimock K.;
RT   "Nucleotide sequence of the human parainfluenza virus 3 matrix protein
RT   gene.";
RL   Nucleic Acids Res. 15:3182-3182(1987).
CC   -!- FUNCTION: The M protein has a crucial role in virus assembly and
CC       interacts with the RNP complex as well as with the viral membrane.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the morbillivirus/respirovirus/rubulavirus M
CC       protein family. {ECO:0000305}.
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DR   EMBL; M16569; AAA46860.1; -; Genomic_RNA.
DR   EMBL; M16458; AAA46858.1; -; Genomic_RNA.
DR   EMBL; D00130; BAA00078.1; -; mRNA.
DR   EMBL; Y00119; CAA68302.1; -; Genomic_RNA.
DR   PIR; A26349; MFNZPT.
DR   PIR; A27511; MFNZP3.
DR   PIR; A29531; MFNZH3.
DR   SMR; P07873; -.
DR   PRIDE; P07873; -.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0019068; P:virion assembly; IEA:InterPro.
DR   Gene3D; 2.70.20.50; -; 1.
DR   Gene3D; 2.70.20.60; -; 1.
DR   InterPro; IPR000982; Matrix.
DR   InterPro; IPR042539; Matrix_C.
DR   InterPro; IPR042540; Matrix_N.
DR   Pfam; PF00661; Matrix; 1.
PE   2: Evidence at transcript level;
KW   Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..353
FT                   /note="Matrix protein"
FT                   /id="PRO_0000142766"
FT   CONFLICT        80
FT                   /note="S -> N (in Ref. 3; BAA00078)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="A -> V (in Ref. 3; BAA00078)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="D -> I (in Ref. 3; BAA00078)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        270
FT                   /note="L -> S (in Ref. 3; BAA00078)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   353 AA;  39501 MW;  A7A60DDDA89F39C9 CRC64;
     MSITNSAIYT FPESSFSENG HIEPLPLKVN EQRKAVPHIR VAKIGNPPKH GSRYLDVFLL
     GFFEMERIKD KYGSVNDLDS DPGYKVCGSG SLPIGLAKYT GNDQELLQAA TKLDIEVRRT
     VKAKEMIVYT VQNIKPELYP WSSRLRKGML FDANKVALAP QCLPLDRSIK FRVIFVNCTA
     IGSITLFKIP KSMASLSLPS TISINLQVHI KTGVQTDSKG IVQILDEKGE KSLNFMVHLG
     LIKRKVGRMY SVEYCKQKIE KMRLIFSLGL VGGISLHVNA TGSISKTLAS QLVFKREICY
     PLMDLNPHLN LVIWASSVEI TRVDAIFQPS LPGEFRYYPN IIAKGVGKIK QWN