ID   MATRX_PIV5              Reviewed;         377 AA.
AC   P16629;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Matrix protein;
DE   AltName: Full=Membrane protein;
GN   Name=M;
OS   Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Mammalian orthorubulavirus 5.
OX   NCBI_TaxID=11208;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2330672; DOI=10.1016/0042-6822(90)90248-p;
RA   Sheshberadaran H., Lamb R.A.;
RT   "Sequence characterization of the membrane protein gene of paramyxovirus
RT   simian virus 5.";
RL   Virology 176:234-243(1990).
RN   [2]
RP   LATE-BUDDING DOMAIN.
RX   PubMed=15709019; DOI=10.1128/jvi.79.5.2988-2997.2005;
RA   Schmitt A.P., Leser G.P., Morita E., Sundquist W.I., Lamb R.A.;
RT   "Evidence for a new viral late-domain core sequence, FPIV, necessary for
RT   budding of a paramyxovirus.";
RL   J. Virol. 79:2988-2997(2005).
CC   -!- FUNCTION: The M protein has a crucial role in virus assembly and
CC       interacts with the RNP complex as well as with the viral membrane.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. The matrix protein contains one L domain: a
CC       FPIV motif.
CC   -!- SIMILARITY: Belongs to the morbillivirus/respirovirus/rubulavirus M
CC       protein family. {ECO:0000305}.
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DR   EMBL; M32248; AAA46901.1; -; Genomic_RNA.
DR   EMBL; AF052755; AAC95514.1; -; Genomic_RNA.
DR   PIR; A34604; MFNZS5.
DR   SMR; P16629; -.
DR   Proteomes; UP000007232; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0046761; P:viral budding from plasma membrane; IDA:UniProtKB.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.20.50; -; 1.
DR   Gene3D; 2.70.20.60; -; 1.
DR   InterPro; IPR000982; Matrix.
DR   InterPro; IPR042539; Matrix_C.
DR   InterPro; IPR042540; Matrix_N.
DR   Pfam; PF00661; Matrix; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Viral budding;
KW   Viral budding via the host ESCRT complexes; Viral envelope protein;
KW   Viral matrix protein; Viral release from host cell; Virion.
FT   CHAIN           1..377
FT                   /note="Matrix protein"
FT                   /id="PRO_0000142777"
FT   MOTIF           20..23
FT                   /note="FPIV motif"
SQ   SEQUENCE   377 AA;  42250 MW;  DF424183C87887C3 CRC64;
     MPSISIPADP TNPRQSIKAF PIVINSDGGE KGRLVKQLRT TYLNDLDTHE PLVTFINTYG
     FIYEQDRGNT IVGEDQLGKK REAVTAAMVT LGCGPNLPSL GNVLGQLREF QVTVRKTSSK
     AEEMVFEIVK YPRIFRGHTL IQKGLVCVSA EKFVKSPGKI QSGMDYLFIP TFLSVTYCPA
     AIKFQVPGPM LKMRSRYTQS LQLELMIRIL CKPDSPLMKV HTPDKEGRGC LVSVWLHVCN
     IFKSGNKNGS EWQEYWMRKC ANMQLEVSIA DMWGPTIIIH ARGHIPKSAK LFFGKGGWSC
     HPLHEVVPSV TKTLWSVGCE ITKAKAIIQE SSISLLVETT DIISPKVKIS SKHRRFVKSN
     WGLFKKTKSL PNLTELE