MATRX_RABVN
ID MATRX_RABVN Reviewed; 202 AA.
AC P25224; Q75T10; Q787B6; Q9IPJ7;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 29-SEP-2021, entry version 76.
DE RecName: Full=Matrix protein;
DE AltName: Full=Phosphoprotein M2;
GN Name=M;
OS Rabies virus (strain Nishigahara RCEH) (RABV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC Lyssavirus.
OX NCBI_TaxID=11298;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=40674; Mammalia.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8470369; DOI=10.1007/bf01702350;
RA Hiramatsu K., Mannen K., Mifune K., Nishizono A., Takita-Sonoda Y.;
RT "Comparative sequence analysis of the M gene among rabies virus strains and
RT its expression by recombinant vaccinia virus.";
RL Virus Genes 7:83-88(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Nishigahara 2001, and RC-HL;
RX PubMed=11270607; DOI=10.1111/j.1348-0421.2001.tb01274.x;
RA Ito N., Kakemizu M., Ito K.A., Yamamoto A., Yoshida Y., Sugiyama M.,
RA Minamoto N.;
RT "A comparison of complete genome sequences of the attenuated RC-HL strain
RT of rabies virus used for production of animal vaccine in Japan, and the
RT parental Nishigahara strain.";
RL Microbiol. Immunol. 45:51-58(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Ni-CE;
RX PubMed=17010466; DOI=10.1016/j.virusres.2006.08.011;
RA Shimizu K., Ito N., Mita T., Yamada K., Hosokawa-Muto J., Sugiyama M.,
RA Minamoto N.;
RT "Involvement of nucleoprotein, phosphoprotein, and matrix protein genes of
RT rabies virus in virulence for adult mice.";
RL Virus Res. 123:154-160(2007).
CC -!- FUNCTION: Plays a major role in assembly, budding and uncoating of
CC virion after membrane fusion. Completely covers the ribonucleoprotein
CC coil and keep it in condensed bullet-shaped form. Inhibits viral
CC transcription and stimulates replication. Plays a major role in early
CC induction of TRAIL-mediated apoptosis in infected neurons.
CC {ECO:0000250|UniProtKB:P16287}.
CC -!- SUBUNIT: Homomultimer. Interacts with nucleoprotein and with the
CC cytoplasmic domain of glycoprotein. Interacts with host ATP6V1A; this
CC interaction plays an important role in virion uncoating after viral
CC entry. {ECO:0000250|UniProtKB:P16287}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P16287};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:P16287}. Host
CC endomembrane system {ECO:0000250|UniProtKB:P16287}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:P16287}. Host cytoplasm
CC {ECO:0000250|UniProtKB:P16287}.
CC -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC essential for viral particle budding. They recruit proteins of the host
CC ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY
CC motif which potentially interacts with the WW domain 3 of NEDD4 E3
CC ubiquitin ligase (Potential). {ECO:0000305}.
CC -!- MISCELLANEOUS: Most abundant protein in the virion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lyssavirus matrix protein family.
CC {ECO:0000305}.
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DR EMBL; D10482; BAA01285.1; -; Genomic_RNA.
DR EMBL; AB044824; BAA96804.1; -; Genomic_RNA.
DR EMBL; AB009663; BAA24085.1; -; Genomic_RNA.
DR EMBL; AB128149; BAD04912.1; -; Genomic_RNA.
DR PIR; JQ1113; MFVNNA.
DR SMR; P25224; -.
DR Proteomes; UP000006366; Genome.
DR Proteomes; UP000007309; Genome.
DR Proteomes; UP000007310; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR Gene3D; 3.10.460.20; -; 1.
DR InterPro; IPR006870; Rhabdo_M.
DR InterPro; IPR038617; Rhabdovirus_M_sf.
DR Pfam; PF04785; Rhabdo_M2; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host membrane; Host-virus interaction; Membrane;
KW Phosphoprotein; Viral budding; Viral budding via the host ESCRT complexes;
KW Viral envelope protein; Viral matrix protein; Viral release from host cell;
KW Virion.
FT CHAIN 1..202
FT /note="Matrix protein"
FT /id="PRO_0000222849"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..151
FT /note="Essential for glycoprotein binding"
FT /evidence="ECO:0000250"
FT MOTIF 35..38
FT /note="PPXY motif"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 11
FT /note="R -> C (in strain: Ni-CE and Nishigahara 2001)"
FT VARIANT 29
FT /note="D -> E (in strain: Ni-CE)"
FT VARIANT 95
FT /note="V -> A (in strain: Ni-CE)"
FT VARIANT 158
FT /note="I -> S (in strain: Ni-CE and Nishigahara 2001)"
FT VARIANT 177
FT /note="T -> A (in strain: Ni-CE and Nishigahara 2001)"
SQ SEQUENCE 202 AA; 23321 MW; 65E592B29F823882 CRC64;
MNILRKIVKN RKDEDTQKPS PASAPPDDDD LWLPPPEYVP LKEFTSKKNM RNFCINGEVK
VCSPNGYSFR ILRHILRSFD EIYSGNHRMI GLVKVVIGLA LSGAPVPEGM NWVYKLRRTL
IFQWADSRGP LEGEELEHSQ EITWDDDTEF VGLQIRVIAR QCHIQGRIWC INTNSRTCQL
WSDMSLKTQM SEEDKDSSLL LE
