ID   MATRX_SVCV              Reviewed;         223 AA.
AC   P04888; Q91DS1;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   29-SEP-2021, entry version 92.
DE   RecName: Full=Matrix protein;
GN   Name=M;
OS   Spring viremia of carp virus (Rhabdovirus carpia).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Sprivivirus.
OX   NCBI_TaxID=696863;
OH   NCBI_TaxID=7962; Cyprinus carpio (Common carp).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6324471; DOI=10.1016/0042-6822(84)90290-3;
RA   Kiuchi A., Roy P.;
RT   "Comparison of the primary sequence of spring viremia of carp virus M
RT   protein with that of vesicular stomatitis virus.";
RL   Virology 134:238-243(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Fijan reference;
RX   PubMed=11900842; DOI=10.1016/s0168-1702(01)00441-5;
RA   Hoffmann B., Schutze H., Mettenleiter T.C.;
RT   "Determination of the complete genomic sequence and analysis of the gene
RT   products of the virus of Spring Viremia of Carp, a fish rhabdovirus.";
RL   Virus Res. 84:89-100(2002).
CC   -!- FUNCTION: Plays a major role in assembly and budding of virion, by
CC       recruiting cellular partners of the ESCRT complexes that play a key
CC       role in releasing the budding particle from the host membrane.
CC       Condensates the ribonucleocapsid core during virus assembly.
CC       {ECO:0000250|UniProtKB:P03519}.
CC   -!- SUBUNIT: Homomultimer. Interacts with viral nucleocapsid. Interacts
CC       with host NEDD4. {ECO:0000250|UniProtKB:P03519}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P03519};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P03519}. Host
CC       endomembrane system {ECO:0000250|UniProtKB:P03519}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P03519}. Host nucleus membrane
CC       {ECO:0000250|UniProtKB:P03519}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P03519}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. M contains a PPXY motif which interacts with
CC       the WW domain 3 of NEDD4. {ECO:0000250|UniProtKB:P03519}.
CC   -!- PTM: Phosphorylated by host. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Most abundant protein in the virion. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vesiculoviruses matrix protein family.
CC       {ECO:0000305}.
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DR   EMBL; K02123; AAA47884.1; -; Genomic_RNA.
DR   EMBL; AJ318079; CAC51335.1; -; Genomic_RNA.
DR   PIR; A04113; MFVNSV.
DR   RefSeq; NP_116746.1; NC_002803.1.
DR   SMR; P04888; -.
DR   GeneID; 921325; -.
DR   KEGG; vg:921325; -.
DR   Proteomes; UP000007541; Genome.
DR   GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.460.10; -; 1.
DR   InterPro; IPR009397; Vesiculo_matrix.
DR   InterPro; IPR036711; VSV_matrix_sf.
DR   Pfam; PF06326; Vesiculo_matrix; 1.
DR   SUPFAM; SSF75404; SSF75404; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host membrane; Host nucleus; Host-virus interaction; Membrane;
KW   Phosphoprotein; Reference proteome; Viral budding;
KW   Viral budding via the host ESCRT complexes; Viral matrix protein;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..223
FT                   /note="Matrix protein"
FT                   /id="PRO_0000222852"
FT   MOTIF           17..20
FT                   /note="PPXY motif"
FT   VARIANT         10
FT                   /note="I -> T (in strain: Fijan reference)"
SQ   SEQUENCE   223 AA;  25641 MW;  5BAC0CCAC0DE8D99 CRC64;
     MSTLRKLFGI KKSKGTPPTY EETLATAPVL MDTHDTHSHS LQWMRYHVEL DVKLDTPLKT
     MSDLLGLLKN WDVDYKGSRN KRRFYRLIMF RCALELKHVS GTYSVDGSAL YSNKVQGSCY
     VPHRFGQMPP FKREIEVFRY PVHQHGYNGM VDLRMSICDL NGEKIGLNLL KECQVAHPNH
     FQKYLEEVGL EAACSATGEW ILDWTFPMPV DVVPRVPSLF MGD