ID   MAX1_METAC              Reviewed;         350 AA.
AC   Q8TPA6;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Sodium/calcium exchanger MaX1;
DE   AltName: Full=Na(+)/Ca(2+) antiporter MaX1;
GN   Name=maX1; OrderedLocusNames=MA_2008;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
RN   [2]
RP   FUNCTION AS AN EXCHANGER, ACTIVITY REGULATION, SUBCELLULAR LOCATION, AND
RP   GENE NAME.
RX   PubMed=22287543; DOI=10.1074/jbc.m111.331280;
RA   Besserer G.M., Nicoll D.A., Abramson J., Philipson K.D.;
RT   "Characterization and purification of a Na+/Ca2+ exchanger from an
RT   archaebacterium.";
RL   J. Biol. Chem. 287:8652-8659(2012).
CC   -!- FUNCTION: Catalyzes Na(+)/Ca(2+) exchange. The transport is
CC       electrogenic with a likely stoichiometry of 3 or more Na(+) for each
CC       Ca(2+). Is K(+)-independent. {ECO:0000269|PubMed:22287543}.
CC   -!- ACTIVITY REGULATION: Calcium transport is inhibited by Na(+), K(+),
CC       Li(+), Mg(2+) or Mn(2+). {ECO:0000269|PubMed:22287543}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22287543};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:22287543}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000305}.
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DR   EMBL; AE010299; AAM05411.1; -; Genomic_DNA.
DR   RefSeq; WP_011022002.1; NC_003552.1.
DR   AlphaFoldDB; Q8TPA6; -.
DR   SMR; Q8TPA6; -.
DR   STRING; 188937.MA_2008; -.
DR   TCDB; 2.A.19.5.4; the ca(2+):cation antiporter (caca) family.
DR   EnsemblBacteria; AAM05411; AAM05411; MA_2008.
DR   GeneID; 1473897; -.
DR   KEGG; mac:MA_2008; -.
DR   HOGENOM; CLU_007948_0_3_2; -.
DR   InParanoid; Q8TPA6; -.
DR   OMA; TRDYGVM; -.
DR   OrthoDB; 45269at2157; -.
DR   PhylomeDB; Q8TPA6; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR   GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   PANTHER; PTHR10846; PTHR10846; 2.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   TIGRFAMs; TIGR00367; TIGR00367; 1.
PE   1: Evidence at protein level;
KW   Antiport; Calcium; Calcium transport; Cell membrane; Ion transport;
KW   Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..350
FT                   /note="Sodium/calcium exchanger MaX1"
FT                   /id="PRO_0000428837"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  38198 MW;  1B5CC243CE137C80 CRC64;
     MITVNFLILL LGLVFLVKGS DYFVKSASTI AKKLGVSEFV IGLTLVAIGT SIPELASSIA
     ASIQQASGIV IGNVVGSNIA NVGLIVGVAA LLSPMKTEID MLKRDGYIML FSAVLFFVFA
     FNRELSMLEA GLFVLLYIAY VFFLFEEAEK YEGKLHFKEF ITYFFKFKYI NSAMQKLNGN
     RNRNSDSDRN SDSGNGNERL EGGFAKDIFT LVLSCAAIVI GAKYFVEESI FFAELLGIPD
     TVIGTTLVAV GTSLPELVVT VSAARQGYGS IALGNVIGSN ITNIFLILGL SGLFYPLSVA
     EMSLFFTTPV MIAISLILLI FISTGWEIKR WEGVVLMMFY VAFLVVLFYI