ARGP_ECO7I
ID ARGP_ECO7I Reviewed; 297 AA.
AC B7NHX5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=HTH-type transcriptional regulator ArgP {ECO:0000255|HAMAP-Rule:MF_00513};
GN Name=argP {ECO:0000255|HAMAP-Rule:MF_00513}; Synonyms=iciA;
GN OrderedLocusNames=ECIAI39_3330;
OS Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI39 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Controls the transcription of genes involved in arginine and
CC lysine metabolism. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; CU928164; CAR19447.1; -; Genomic_DNA.
DR RefSeq; WP_001301058.1; NC_011750.1.
DR RefSeq; YP_002409251.1; NC_011750.1.
DR AlphaFoldDB; B7NHX5; -.
DR SMR; B7NHX5; -.
DR STRING; 585057.ECIAI39_3330; -.
DR EnsemblBacteria; CAR19447; CAR19447; ECIAI39_3330.
DR KEGG; ect:ECIAI39_3330; -.
DR PATRIC; fig|585057.6.peg.3456; -.
DR HOGENOM; CLU_063829_0_0_6; -.
DR OMA; QQWKLDS; -.
DR Proteomes; UP000000749; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00513; HTH_type_ArgP; 1.
DR InterPro; IPR017685; ArgP.
DR InterPro; IPR023490; ArgP_Gammaproteobact.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR03298; argP; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..297
FT /note="HTH-type transcriptional regulator ArgP"
FT /id="PRO_1000127268"
FT DOMAIN 4..60
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
SQ SEQUENCE 297 AA; 33502 MW; 8AD611CB6661E3FE CRC64;
MKRPDYRTLQ ALDAVIRERG FERAAQKLCI TQSAVSQRIK QLENMFGQPL LVRTVPPRPT
EQGQKLLALL RQVELLEEEW LGDEQTGSTP LLLSLAVNAD SLATWLLPAL APVLADSPIR
LNLQVEDETR TQERLRRGEV VGAVSIQHQA LPSCLVDKLG ALDYLFVSSK PFAEKYFPNG
VTRSALLKAP VVAFDHLDDM HQAFLQQNFD LPPGSVPCHI VNSSEAFVQL ARQGTTCCMI
PHLQIEKELT SGELIDLTPG LFQRRMLYWH RFAPESRMMR KVTDALLDYG HKVLRQD