MAXSD_BOMMX
ID MAXSD_BOMMX Reviewed; 270 AA.
AC Q5GC91;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Maximins-S type D;
DE Contains:
DE RecName: Full=Maximin-S1;
DE Contains:
DE RecName: Full=Maximin-S3;
DE Contains:
DE RecName: Full=Maximin-S5;
DE Contains:
DE RecName: Full=Maximin-S2;
DE Contains:
DE RecName: Full=Maximin-S4;
DE Flags: Precursor;
OS Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Bombinatoridae; Bombina.
OX NCBI_TaxID=161274;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF MAXIMIN-S1, SYNTHESIS OF
RP MAXIMIN-S4, AMIDATION AT ASN-83; LYS-118; ASN-153; ASN-188; LYS-223 AND
RP LYS-258, AND MASS SPECTROMETRY.
RC TISSUE=Skin, and Skin secretion;
RX PubMed=15649437; DOI=10.1016/j.bbrc.2004.12.094;
RA Wang T., Zhang J., Shen J.-H., Jin Y., Lee W.-H., Zhang Y.;
RT "Maximins S, a novel group of antimicrobial peptides from toad Bombina
RT maxima.";
RL Biochem. Biophys. Res. Commun. 327:945-951(2005).
CC -!- FUNCTION: Maximin-S1 has no antimicrobial activity. Has no hemolytic
CC activity.
CC -!- FUNCTION: Maximin-S2 has an activity against mycoplasma but has no
CC activity against common Gram-positive and Gram-negative bacteria nor
CC fungi. Has no hemolytic activity (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Maximin-S3 has an activity against mycoplasma but has no
CC activity against common Gram-positive and Gram-negative bacteria nor
CC fungi. Has no hemolytic activity (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Maximin-S4 has an activity against mycoplasma but has no
CC activity against common Gram-positive and Gram-negative bacteria nor
CC fungi. Has no hemolytic activity.
CC -!- FUNCTION: Maximin-S5 has an activity against mycoplasma but has no
CC activity against common Gram-positive and Gram-negative bacteria nor
CC fungi. Has no hemolytic activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC -!- MASS SPECTROMETRY: [Maximin-S3]: Mass=1973.92; Method=MALDI;
CC Note=Maximin-S2.; Evidence={ECO:0000269|PubMed:15649437};
CC -!- MASS SPECTROMETRY: [Maximin-S5]: Mass=1959.22; Method=MALDI;
CC Note=Maximin-S3.; Evidence={ECO:0000269|PubMed:15649437};
CC -!- MASS SPECTROMETRY: [Maximin-S3]: Mass=2087.90; Method=MALDI;
CC Note=Maximin-S4.; Evidence={ECO:0000269|PubMed:15649437};
CC -!- MASS SPECTROMETRY: [Maximin-S4]: Mass=1987.08; Method=MALDI;
CC Note=Maximin-S5.; Evidence={ECO:0000269|PubMed:15649437};
CC -!- SIMILARITY: Belongs to the maximin-S family. {ECO:0000305}.
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DR EMBL; AY652774; AAV97982.1; -; mRNA.
DR AlphaFoldDB; Q5GC91; -.
DR SMR; Q5GC91; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..35
FT /id="PRO_0000010285"
FT PEPTIDE 36..49
FT /note="Maximin-S1"
FT /id="PRO_0000010286"
FT PROPEP 52..65
FT /id="PRO_0000010287"
FT PEPTIDE 66..83
FT /note="Maximin-S3"
FT /id="PRO_0000010288"
FT PROPEP 87..100
FT /id="PRO_0000010289"
FT PEPTIDE 101..118
FT /note="Maximin-S5"
FT /id="PRO_0000010290"
FT PROPEP 122..135
FT /id="PRO_0000010291"
FT PEPTIDE 136..153
FT /note="Maximin-S2"
FT /id="PRO_0000010292"
FT PROPEP 157..170
FT /id="PRO_0000010293"
FT PEPTIDE 171..188
FT /note="Maximin-S3"
FT /id="PRO_0000010294"
FT PROPEP 192..205
FT /id="PRO_0000010295"
FT PEPTIDE 206..223
FT /note="Maximin-S4"
FT /id="PRO_0000010296"
FT PROPEP 227..240
FT /id="PRO_0000010297"
FT PEPTIDE 241..258
FT /note="Maximin-S5"
FT /id="PRO_0000010298"
FT PROPEP 262..270
FT /id="PRO_0000010299"
FT MOD_RES 83
FT /note="Asparagine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
FT MOD_RES 118
FT /note="Lysine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
FT MOD_RES 153
FT /note="Asparagine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
FT MOD_RES 188
FT /note="Asparagine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
FT MOD_RES 223
FT /note="Lysine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
FT MOD_RES 258
FT /note="Lysine amide"
FT /evidence="ECO:0000269|PubMed:15649437"
SQ SEQUENCE 270 AA; 30375 MW; 2AFDFA7DDB03D982 CRC64;
MNFNYFILVL FFITSGHAKS ETREVHQEAE NHIKRGSNTG FNFKTLDKEK RSAEEQNLAE
HLVTRGSNKG FNFMVDMINA LSNGKRSAEE QDLAEDLVTR GSNKGFNFMV DMIQALSKGK
RSAEDQDLAE DLVTRGSNKG FNFMVDMIQA LSNGKRSAEE QDLAEHLVTR GSNKGFNFMV
DMINALSNGK RSAEEQDLVE DLVTRRSNKG FNFMVDMIQA LSKGKRSAEE QDLAEDLVTR
GSNKGFNFMV DMIQALSKGK RSAEQEKDMK
