MAX_CHICK
ID MAX_CHICK Reviewed; 160 AA.
AC P52162;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein max;
DE AltName: Full=Myc-associated factor X;
GN Name=MAX;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS LONG AND SHORT).
RC TISSUE=Fibroblast;
RX PubMed=8290277;
RA Sollenberger K.G., Kao T.L., Taparowsky E.J.;
RT "Structural analysis of the chicken max gene.";
RL Oncogene 9:661-664(1994).
CC -!- FUNCTION: Transcription regulator. Forms a sequence-specific DNA-
CC binding protein complex with MYC or MAD which recognizes the core
CC sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional
CC activator, whereas the MAD-MAX complex is a repressor (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MYC or MAD. Component of some
CC MLL1/MLL complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P52162-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P52162-2; Sequence=VSP_002120;
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MAX family. {ECO:0000305}.
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DR EMBL; L12469; AAA16834.1; -; Unassigned_DNA.
DR PIR; I50379; I50379.
DR RefSeq; XP_015141578.1; XM_015286092.1. [P52162-1]
DR AlphaFoldDB; P52162; -.
DR BMRB; P52162; -.
DR SMR; P52162; -.
DR MINT; P52162; -.
DR STRING; 9031.ENSGALP00000040991; -.
DR Ensembl; ENSGALT00000052061; ENSGALP00000057649; ENSGALG00000032249. [P52162-2]
DR Ensembl; ENSGALT00000065978; ENSGALP00000044694; ENSGALG00000032249. [P52162-1]
DR GeneID; 100858676; -.
DR KEGG; gga:100858676; -.
DR CTD; 4149; -.
DR VEuPathDB; HostDB:geneid_100858676; -.
DR eggNOG; KOG2483; Eukaryota.
DR GeneTree; ENSGT00530000064011; -.
DR HOGENOM; CLU_109424_1_0_1; -.
DR InParanoid; P52162; -.
DR OMA; QIQTNYS; -.
DR OrthoDB; 1545748at2759; -.
DR PhylomeDB; P52162; -.
DR PRO; PR:P52162; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000032249; Expressed in cerebellum and 13 other tissues.
DR ExpressionAtlas; P52162; baseline and differential.
DR GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037933; MAX-like.
DR PANTHER; PTHR10328; PTHR10328; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Activator; Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..160
FT /note="Protein max"
FT /id="PRO_0000127272"
FT DOMAIN 23..74
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..102
FT /note="Leucine-zipper"
FT REGION 105..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 13..21
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_002120"
SQ SEQUENCE 160 AA; 18184 MW; F09B16D1AB379A7E CRC64;
MSDNDDIEVE SDEEQPRFQS AADKRAHHNA LERKRRDHIK DSFHSLRDSV PSLQGEKASR
AQILDKATEY IQYMRRKNHT HQQDIDDLKR QNALLEQQVR ALEKARSSAQ LQANYPAADS
SLYTNPKGST ISAFDGGSDS SSDSEPDEPQ SRKKLRMEAS
