ID   MAZE2_MYCBO             Reviewed;          82 AA.
AC   P0CL58; A0A1R3XZV3; X2BJQ6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Antitoxin MazE2;
GN   Name=mazE2; OrderedLocusNames=BQ2027_MB2014A;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF2 toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P9WJ87}.
CC   -!- SUBUNIT: Probably forms a complex with cognate toxin MazF2.
CC       {ECO:0000250|UniProtKB:P9WJ87}.
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DR   EMBL; LT708304; SIU00621.1; -; Genomic_DNA.
DR   RefSeq; WP_003410014.1; NC_002945.4.
DR   AlphaFoldDB; P0CL58; -.
DR   SMR; P0CL58; -.
DR   EnsemblBacteria; SIU00621; SIU00621; BQ2027_MB2014A.
DR   GeneID; 45425970; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Antitoxin MazE2"
FT                   /id="PRO_0000406296"
SQ   SEQUENCE   82 AA;  9290 MW;  AE34DE0F70F68114 CRC64;
     MKTAISLPDE TFDRVSRRAS ELGMSRSEFF TKAAQRYLHE LDAQLLTGQI DRALESIHGT
     DEAEALAVAN AYRVLETMDD EW