ID   MAZE2_MYCTU             Reviewed;          81 AA.
AC   O06779; L0T764;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Probable antitoxin MazE2 {ECO:0000305};
GN   Name=mazE2; Synonyms=mazE-mt4 {ECO:0000303|PubMed:16611633};
GN   OrderedLocusNames=Rv0660c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   GENE NAME, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16611633; DOI=10.1074/jbc.m512693200;
RA   Zhu L., Zhang Y., Teh J.S., Zhang J., Connell N., Rubin H., Inouye M.;
RT   "Characterization of mRNA interferases from Mycobacterium tuberculosis.";
RL   J. Biol. Chem. 281:18638-18643(2006).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       {ECO:0000305}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF2.
CC       {ECO:0000250|UniProtKB:O53451}.
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DR   EMBL; AL123456; CCP43403.1; -; Genomic_DNA.
DR   PIR; G70534; G70534.
DR   RefSeq; NP_215174.1; NC_000962.3.
DR   RefSeq; WP_003403381.1; NZ_NVQJ01000007.1.
DR   AlphaFoldDB; O06779; -.
DR   SMR; O06779; -.
DR   STRING; 83332.Rv0660c; -.
DR   PaxDb; O06779; -.
DR   PRIDE; O06779; -.
DR   DNASU; 888141; -.
DR   GeneID; 45424620; -.
DR   GeneID; 888141; -.
DR   KEGG; mtu:Rv0660c; -.
DR   PATRIC; fig|83332.111.peg.733; -.
DR   TubercuList; Rv0660c; -.
DR   OMA; EDWTDWA; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002145; CopG.
DR   Pfam; PF01402; RHH_1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..81
FT                   /note="Probable antitoxin MazE2"
FT                   /id="PRO_0000406297"
SQ   SEQUENCE   81 AA;  9169 MW;  29985341768D033D CRC64;
     MLSFRADDHD VDLADAWARR LHIGRSELLR DALRRHLAAL AADQDVQAYT ERPLTDDENA
     LAEIADWGPA EDWADWADAA R