ID   MAZE5_MYCTU             Reviewed;         125 AA.
AC   P9WJ89; L0TAV7; P95271; Q7D7Q7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Antitoxin MazE5 {ECO:0000305};
GN   Name=mazE5; Synonyms=mazE-mt5 {ECO:0000303|PubMed:16611633};
GN   OrderedLocusNames=Rv1943c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   GENE NAME, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16611633; DOI=10.1074/jbc.m512693200;
RA   Zhu L., Zhang Y., Teh J.S., Zhang J., Connell N., Rubin H., Inouye M.;
RT   "Characterization of mRNA interferases from Mycobacterium tuberculosis.";
RL   J. Biol. Chem. 281:18638-18643(2006).
RN   [4]
RP   INDUCTION.
RX   PubMed=19389781; DOI=10.1099/mic.0.027086-0;
RA   de la Paz Santangelo M., Klepp L., Nunez-Garcia J., Blanco F.C., Soria M.,
RA   Garcia-Pelayo M.C., Bianco M.V., Cataldi A.A., Golby P., Jackson M.,
RA   Gordon S.V., Bigi F.;
RT   "Mce3R, a TetR-type transcriptional repressor, controls the expression of a
RT   regulon involved in lipid metabolism in Mycobacterium tuberculosis.";
RL   Microbiology 155:2245-2255(2009).
RN   [5]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       MazF5. {ECO:0000269|PubMed:20011113}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF5.
CC       {ECO:0000250|UniProtKB:O53451}.
CC   -!- INDUCTION: Repressed by Mce3R. {ECO:0000269|PubMed:19389781}.
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DR   EMBL; AL123456; CCP44710.1; -; Genomic_DNA.
DR   PIR; C70637; C70637.
DR   RefSeq; NP_216459.1; NC_000962.3.
DR   RefSeq; WP_003409780.1; NZ_NVQJ01000034.1.
DR   AlphaFoldDB; P9WJ89; -.
DR   SMR; P9WJ89; -.
DR   STRING; 83332.Rv1943c; -.
DR   PaxDb; P9WJ89; -.
DR   DNASU; 885605; -.
DR   GeneID; 45427974; -.
DR   GeneID; 885605; -.
DR   KEGG; mtu:Rv1943c; -.
DR   PATRIC; fig|83332.111.peg.2161; -.
DR   TubercuList; Rv1943c; -.
DR   eggNOG; ENOG50345T0; Bacteria.
DR   OMA; LNEPDEW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..125
FT                   /note="Antitoxin MazE5"
FT                   /id="PRO_0000406299"
SQ   SEQUENCE   125 AA;  13592 MW;  C4EE6301FA8ACD70 CRC64;
     MKTARLQVTL RCAVDLINSS SDQCFARIEH VASDQADPRP GVWHSSGMNR IRLSTTVDAA
     LLTSARDMRA GITDAALIDE ALAALLARHR SAEVDASYAA YDKHPVDEPD EWGDLASWRR
     AAGDS