ID   MAZE6_MYCTO             Reviewed;          82 AA.
AC   P9WJ86; F2GGA0; P0CL59; Q8VJS6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Antitoxin MazE6;
GN   Name=mazE6; OrderedLocusNames=MT2047;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF6 toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P9WJ87}.
CC   -!- SUBUNIT: Probably forms a complex with cognate toxin MazF6 which
CC       neutralizes the toxin. {ECO:0000250|UniProtKB:P9WJ87}.
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DR   EMBL; AE000516; AAK46324.1; -; Genomic_DNA.
DR   RefSeq; WP_003410014.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJ86; -.
DR   SMR; P9WJ86; -.
DR   EnsemblBacteria; AAK46324; AAK46324; MT2047.
DR   GeneID; 45425970; -.
DR   KEGG; mtc:MT2047; -.
DR   PATRIC; fig|83331.31.peg.2204; -.
DR   HOGENOM; CLU_179926_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Antitoxin MazE6"
FT                   /id="PRO_0000427873"
SQ   SEQUENCE   82 AA;  9290 MW;  AE34DE0F70F68114 CRC64;
     MKTAISLPDE TFDRVSRRAS ELGMSRSEFF TKAAQRYLHE LDAQLLTGQI DRALESIHGT
     DEAEALAVAN AYRVLETMDD EW