ID   MAZE8_MYCTU             Reviewed;          82 AA.
AC   P0CL60; L0TC12;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Antitoxin MazE8 {ECO:0000305};
GN   Name=mazE8; OrderedLocusNames=Rv2274A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Its cognate toxin is MazF8.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF8.
CC       {ECO:0000250|UniProtKB:O53451}.
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DR   EMBL; AL123456; CCP45056.1; -; Genomic_DNA.
DR   RefSeq; WP_003903832.1; NC_000962.3.
DR   RefSeq; YP_007410963.1; NC_000962.3.
DR   AlphaFoldDB; P0CL60; -.
DR   STRING; 83332.Rv2274A; -.
DR   GeneID; 14515891; -.
DR   KEGG; mtu:Rv2274A; -.
DR   TubercuList; Rv2274A; -.
DR   Proteomes; UP000001584; Chromosome.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Antitoxin MazE8"
FT                   /id="PRO_0000406302"
SQ   SEQUENCE   82 AA;  9256 MW;  CB3F469DE2F5438D CRC64;
     MAEPETLPGR WLPECACLAE TVSWEQSRLW SRLLCRPHFR HALPGLTGGS ASRPSARSAR
     LVRQPRMTLF SLDHRDGVDA RC