ID   MAZE_ECO57              Reviewed;          82 AA.
AC   P0AE73; P18534;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; Synonyms=chpAI, chpR; OrderedLocusNames=Z4098, ECs3643;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to its cognate MazF endoribonuclease toxin
CC       and neutralizes its activity. Both MazE and MazE-MazF bind to the
CC       promoter region of the mazE-mazF operon to inhibit their transcription.
CC       {ECO:0000250|UniProtKB:P0AE72}.
CC   -!- SUBUNIT: Forms a heterohexamer composed of alternating toxin and
CC       antitoxin homodimers MazF(2)-MazE(2)-MazF(2) which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0AE72}.
CC   -!- SIMILARITY: Belongs to the PemI family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57896.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37066.1; -; Genomic_DNA.
DR   PIR; C91084; C91084.
DR   PIR; D85929; D85929.
DR   RefSeq; NP_311670.1; NC_002695.1.
DR   RefSeq; WP_000581937.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AE73; -.
DR   BMRB; P0AE73; -.
DR   SMR; P0AE73; -.
DR   STRING; 155864.EDL933_3961; -.
DR   EnsemblBacteria; AAG57896; AAG57896; Z4098.
DR   EnsemblBacteria; BAB37066; BAB37066; ECs_3643.
DR   GeneID; 66673350; -.
DR   GeneID; 916553; -.
DR   KEGG; ece:Z4098; -.
DR   KEGG; ecs:ECs_3643; -.
DR   PATRIC; fig|386585.9.peg.3807; -.
DR   eggNOG; COG2336; Bacteria.
DR   HOGENOM; CLU_150554_1_0_6; -.
DR   OMA; WGNSPSV; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR037914; SpoVT-AbrB_sf.
DR   Pfam; PF04014; MazE_antitoxin; 1.
DR   SMART; SM00966; SpoVT_AbrB; 1.
DR   SUPFAM; SSF89447; SSF89447; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000089650"
FT   DOMAIN          4..49
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ   SEQUENCE   82 AA;  9356 MW;  CD452A9AA4FB362E CRC64;
     MIHSSVKRWG NSPAVRIPAT LMQALNLNID DEVKIDLVDG KLIIEPVRKE PVFTLAELVN
     DITPENLHEN IDWGEPKDKE VW