MAZE_STAA1
ID MAZE_STAA1 Reviewed; 56 AA.
AC A7X4P6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Antitoxin MazE;
GN Name=mazE; OrderedLocusNames=SAHV_2054;
OS Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=418127;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu3 / ATCC 700698;
RX PubMed=17954695; DOI=10.1128/aac.00534-07;
RA Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT "Mutated response regulator graR is responsible for phenotypic conversion
RT of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT resistance to vancomycin-intermediate resistance.";
RL Antimicrob. Agents Chemother. 52:45-53(2008).
CC -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR EMBL; AP009324; BAF78937.1; -; Genomic_DNA.
DR RefSeq; WP_000948331.1; NZ_CTYB01000037.1.
DR AlphaFoldDB; A7X4P6; -.
DR SMR; A7X4P6; -.
DR KEGG; saw:SAHV_2054; -.
DR HOGENOM; CLU_3012108_0_0_9; -.
DR OMA; AYSVECE; -.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.1220.10; -; 1.
DR InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE 3: Inferred from homology;
KW Toxin-antitoxin system.
FT CHAIN 1..56
FT /note="Antitoxin MazE"
FT /id="PRO_0000330714"
SQ SEQUENCE 56 AA; 6252 MW; B6DA0AFB386D7691 CRC64;
MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE