ID   MAZE_STAA3              Reviewed;          56 AA.
AC   P0C7B5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SAUSA300_2026.1;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; CP000255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_000948331.1; NZ_CP027476.1.
DR   AlphaFoldDB; P0C7B5; -.
DR   SMR; P0C7B5; -.
DR   OMA; AYSVECE; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330720"
SQ   SEQUENCE   56 AA;  6252 MW;  B6DA0AFB386D7691 CRC64;
     MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE