ID   MAZE_STAA8              Reviewed;          56 AA.
AC   Q2FWI7; Q9ZAH4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SAOUHSC_02304;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34.
RX   PubMed=9756984; DOI=10.1016/s0378-1119(98)00404-1;
RA   Kullik I., Jenni R., Berger-Baechi B.;
RT   "Sequence of the putative alanine racemase operon in Staphylococcus aureus:
RT   insertional interruption of this operon reduces D-alanine substitution of
RT   lipoteichoic acid and autolysis.";
RL   Gene 219:9-17(1998).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31338.1; -; Genomic_DNA.
DR   EMBL; Y16431; CAA76222.1; -; Genomic_DNA.
DR   RefSeq; WP_000948331.1; NZ_LS483365.1.
DR   RefSeq; YP_500783.1; NC_007795.1.
DR   AlphaFoldDB; Q2FWI7; -.
DR   SMR; Q2FWI7; -.
DR   STRING; 1280.SAXN108_2314; -.
DR   EnsemblBacteria; ABD31338; ABD31338; SAOUHSC_02304.
DR   GeneID; 3919175; -.
DR   KEGG; sao:SAOUHSC_02304; -.
DR   PATRIC; fig|93061.5.peg.2088; -.
DR   eggNOG; ENOG50305BV; Bacteria.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   PRO; PR:Q2FWI7; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330718"
SQ   SEQUENCE   56 AA;  6252 MW;  B6DA0AFB386D7691 CRC64;
     MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE