ID   MAZE_STAAC              Reviewed;          56 AA.
AC   Q5HED2; P95839;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SACOL2059;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-56.
RX   PubMed=8830703; DOI=10.1128/jb.178.20.6036-6042.1996;
RA   Wu S.-W., de Lencastre H., Tomasz A.;
RT   "Sigma-B, a putative operon encoding alternate sigma factor of
RT   Staphylococcus aureus RNA polymerase: molecular cloning and DNA
RT   sequencing.";
RL   J. Bacteriol. 178:6036-6042(1996).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW37021.1; -; Genomic_DNA.
DR   EMBL; Y09929; CAA71063.1; -; Genomic_DNA.
DR   RefSeq; WP_000948331.1; NC_002951.2.
DR   AlphaFoldDB; Q5HED2; -.
DR   SMR; Q5HED2; -.
DR   EnsemblBacteria; AAW37021; AAW37021; SACOL2059.
DR   KEGG; sac:SACOL2059; -.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330711"
SQ   SEQUENCE   56 AA;  6252 MW;  B6DA0AFB386D7691 CRC64;
     MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE