ID   MAZE_STAAM              Reviewed;          56 AA.
AC   Q99SI6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SAV2069;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SUBUNIT: Forms a complex with cognate toxin MazF which inhibits the
CC       endoribonuclease activity of MazF. {ECO:0000250|UniProtKB:P0C7B4}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58231.1; -; Genomic_DNA.
DR   RefSeq; WP_000948331.1; NC_002758.2.
DR   AlphaFoldDB; Q99SI6; -.
DR   SMR; Q99SI6; -.
DR   PaxDb; Q99SI6; -.
DR   EnsemblBacteria; BAB58231; BAB58231; SAV2069.
DR   KEGG; sav:SAV2069; -.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   BioCyc; SAUR158878:SAV_RS11325-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330715"
SQ   SEQUENCE   56 AA;  6252 MW;  B6DA0AFB386D7691 CRC64;
     MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE