ID   MAZE_STAAN              Reviewed;          56 AA.
AC   Q7A4G8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Antitoxin MazE;
GN   Name=mazE; OrderedLocusNames=SA1873.1; ORFNames=SAS067;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=24748664; DOI=10.1093/nar/gku266;
RA   Zorzini V., Buts L., Sleutel M., Garcia-Pino A., Talavera A., Haesaerts S.,
RA   De Greve H., Cheung A., van Nuland N.A., Loris R.;
RT   "Structural and biophysical characterization of Staphylococcus aureus
RT   SaMazF shows conservation of functional dynamics.";
RL   Nucleic Acids Res. 42:6709-6725(2014).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Labile antitoxin that binds to cognate MazF toxin and counteracts its
CC       endoribonuclease activity. {ECO:0000269|PubMed:24748664}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with cognate toxin MazF which
CC       inhibits the endoribonuclease activity of MazF.
CC       {ECO:0000269|PubMed:24748664}.
CC   -!- SIMILARITY: Belongs to the MazE/EndoAI family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43156.1; -; Genomic_DNA.
DR   PIR; C89999; C89999.
DR   RefSeq; WP_000948331.1; NC_002745.2.
DR   AlphaFoldDB; Q7A4G8; -.
DR   SMR; Q7A4G8; -.
DR   EnsemblBacteria; BAB43156; BAB43156; BAB43156.
DR   KEGG; sau:SAS067; -.
DR   HOGENOM; CLU_3012108_0_0_9; -.
DR   OMA; AYSVECE; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
PE   1: Evidence at protein level;
KW   Toxin-antitoxin system.
FT   CHAIN           1..56
FT                   /note="Antitoxin MazE"
FT                   /id="PRO_0000330717"
SQ   SEQUENCE   56 AA;  6252 MW;  B6DA0AFB386D7691 CRC64;
     MLSFSQNRSH SLEQSLKEGY SQMADLNLSL ANEAFPIECE ACDCNETYLS SNSTNE